B2A611

PR
Gene name
addB
Protein name
ATP-dependent helicase/deoxyribonuclease subunit B
Names
ATP-dependent helicase/nuclease AddB
Species
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
KEGG Pathway
nth:Nther_1856
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

247-317 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2A611

Entry ID Method Resolution Chain Position Source
AF-B2A611-F1 Predicted AlphaFoldDB

No variants for B2A611

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2A611

No associated diseases with B2A611

3 regional properties for B2A611

Type Name Position InterPro Accession
active_site Lipase, GDXG, putative histidine active site 87 - 103 IPR002168
domain Alpha/beta hydrolase fold-3 87 - 295 IPR013094
active_site Lipase, GDXG, putative serine active site 159 - 171 IPR033140

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

7 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
5'-3' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
double-stranded DNA binding Binding to double-stranded DNA.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSVKFLLGRA GSGKTSYIID SITEQLKAAP DGDPIIFLVP EQATFQMEQA ILRRSDISGF
70 80 90 100 110 120
SRLHILSFQR LSQKVLEEQG GIAKADLSDT GKEMIIKNIL LQRKDDLEIL EKVAVKSGFS
130 140 150 160 170 180
EKLSRLISEA RMYEITPEML EQISQELDLI HLKQKLQEIS QVFTDYETFL QHQGYHHQED
190 200 210 220 230 240
RLSKAGQKME GNNISFLAGS TCYIDGFSGF TPQELKLLEG LLTKCSNIEL ALTLPPQFTG
250 260 270 280 290 300
KIDDELHLFH PTLKTYNQVW ELAVNNDIEI KKSKHFPNEN EEHRSASSLP RFKDNPALAH
310 320 330 340 350 360
LEKEWGKNKI NPYDSEPTGL SIVEGTNLRN EIDKIAREIK LLVRDHGMRY KDIAVIVREL
370 380 390 400 410 420
ESYEPVIKAV FNDYKIPHFL DRKEPVHHHP LVEFLRSSVE TVISNWDYEP LFRMLKTGLL
430 440 450 460 470 480
PISSEEIFQV ENYVLAHGIS GKDWKKQGKW NFIANFDLER ENIAPSNRNK QYLSEINSIK
490 500 510 520 530 540
GKVRDTLLEF DSKLRGINKS ESLSAQFKNQ EAEEDNLLSV REISTYLWEL IEQLQIEYQL
550 560 570 580 590 600
EEWSLEAEER KDFVEMQLHN QLWDTVIDLL DQMVTFLGEQ KVTLSEYLQI IESGLANIKL
610 620 630 640 650 660
GLLPATLDQV LVGTADRSRY HEIKVLFMAG VSDGLYPAKI DDDGIIDDRE RITLRQHDVE
670 680 690 700 710 720
FAPTTEQKLY QEQYLIYNVL TQPSQKLYLS YPAADSEGRT MSPSTIISDI QEMFPELFQE
730 740 750 760 770 780
YQNDGPENDE DFRQYIIDGK KAVSNLIKLI NKVGHPEKLA EDKQQLLAYL INEHPDLFYS
790 800 810 820 830 840
TPEIKALDYK KSLSPLTQEV IDKLYPNKIA TSVSGLESFC QCPFRHFAEQ NLRLKEREYF
850 860 870 880 890 900
RLEPASLGLF YHAGLKLFWD KLQENNLTWH KLKTEEREAL VSEIVEVLSE RLKNRILLAS
910 920 930 940 950 960
ERYKYFKKKL HELLSRAVEV LSWYSDDKGF YPVGSEIGFG KDEPLSTLEL ELPSFPNKKV
970 980 990 1000 1010 1020
QLKGRIDRID TGKKDGDLYL RVIDYKGKSK NLELRDLYYG LDLQLAAYMT VAMRNSDKLT
1030 1040 1050 1060 1070 1080
GDQMFPGGML YFGVENPVVP TDKPVSPAQA RDKLKSTLKM RGYLIDDEEV LDLMTREDEN
1090 1100 1110 1120 1130 1140
SQDLLPYKLR TSSPGFYKNS KVLSEQEFLA VLNYTESKLV ELAERVLSGE IAPYPYKDGG
1150 1160 1170 1180
YSACTYCPYL AVCQFDLNYK EHKFWNVPAK GDYLSLILEE MEEVKE