B2A526

PR
Gene name
dxs
Protein name
1-deoxy-D-xylulose-5-phosphate synthase
Names
1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS
Species
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
KEGG Pathway
nth:Nther_1694
EC number
2.2.1.7: Transketolases and transaldolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

79-153 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2A526

Entry ID Method Resolution Chain Position Source
AF-B2A526-F1 Predicted AlphaFoldDB

No variants for B2A526

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2A526

No associated diseases with B2A526

4 regional properties for B2A526

Type Name Position InterPro Accession
domain Transketolase, N-terminal 30 - 49 IPR005474
domain Transketolase-like, pyrimidine-binding domain 317 - 481 IPR005475
binding_site Transketolase binding site 423 - 439 IPR020826
domain Transketolase, C-terminal domain 494 - 612 IPR033248

Functions

Description
EC Number 2.2.1.7 Transketolases and transaldolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
1-deoxy-D-xylulose-5-phosphate synthase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2).
magnesium ion binding Binding to a magnesium (Mg) ion.
thiamine pyrophosphate binding Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

3 GO annotations of biological process

Name Definition
1-deoxy-D-xylulose 5-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.
terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.
thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTKLLSYINT SEDLKHLSTE DLNKLAEELR EFLISSISIT GGHLAPNLGV VELTLAIHKV
70 80 90 100 110 120
FSPIQDKIVW DVGHQSYIHK ILTGRKEQFS TLRQFGGLSG FPKPEESRYD AFGTGHSSTS
130 140 150 160 170 180
ISAALGMAKA RDLQGSNEEV LAVIGDGAMT GGMAFEAMNH AGHEQANMTV ILNDNEMSIG
190 200 210 220 230 240
TNVGALSSYL SRLRTDPKYH RIKEDVEFLL KRIPAIGGKM MKSVERVKDS MKYLMVSGML
250 260 270 280 290 300
FEELGFTYIG PIDGHNIPQL MEVLNNAKDK NGPVLVHVIT KKGKGYEPAE KFPDKFHGTG
310 320 330 340 350 360
PFEIETGNAP KKAETAPSYS KVFGDTISEI ARKNESVVAI TAAMKDGTGL TNFAREFPER
370 380 390 400 410 420
FFDVGIAEQH AITFAAGLAR KGFKPVVAIY STFLQRAYDQ IIHDVCMQDN PVIFAIDRAG
430 440 450 460 470 480
IVGGDGETHQ GLYDLSYLRS IPNLIVMAPK DEAELQRMLN TAVNINKPVA IRYPRGKGEG
490 500 510 520 530 540
VTLWENMTPI PLYKGETIRE GSQVAMIGVG KMVPDMLEVA DMLKKEGIEP TVFNARFVKP
550 560 570 580 590 600
LDESSILEIA QKHEYIYTFE ENTELGGFGS QVLECLSKHG LAHKLIDRFC LPDEYIPHGD
610 620 630
RSKVLSQYSL HSQELINKIL NRLRGEQIEQ G