B2A4Q0
Gene name |
rpoA |
Protein name |
DNA-directed RNA polymerase subunit alpha |
Names |
RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha |
Species |
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF) |
KEGG Pathway |
nth:Nther_0223 |
EC number |
2.7.7.6: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B2A4Q0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B2A4Q0-F1 | Predicted | AlphaFoldDB |
No variants for B2A4Q0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B2A4Q0 | |||||
No associated diseases with B2A4Q0
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.6 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| DNA-directed RNA polymerase complex | A protein complex that possesses DNA-directed RNA polymerase activity. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIEIEKPQIE | CHEMNEESTY | GKFVIEPLER | GYGTTLGNSL | RRILLSSLPG | AAVTSVKIDG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLHEFSSIPG | VVEDTTEIVL | NLKRLALKIH | SDENQVLTLE | KEGKGPVTAG | DIQAGSDVDV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| INPELHIATL | SEDTRLYMEI | TAKNGRGYVR | AERNKEPEQP | IGLIPVDSVF | TPVTKANFYV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DDTRVGQVTD | YDRLTLEVWT | DGSLKPDEAV | SMSAKIMQEH | LDLFINLTEK | ATDMEVMVEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EEDNKEKIME | LSIDELDLSV | RSYNCLKRAG | INTIGELTQK | TPEDMMKVRN | LGKKSLEEVK |
| 310 | |||||
| NKLTELGLSL | KDSKE |