B1YMD8

PR
Gene name
mutL
Protein name
DNA mismatch repair protein MutL
Names
Species
Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 / 255-15)
KEGG Pathway
esi:Exig_1045
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

300-441 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1YMD8

Entry ID Method Resolution Chain Position Source
AF-B1YMD8-F1 Predicted AlphaFoldDB

No variants for B1YMD8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1YMD8

No associated diseases with B1YMD8

3 regional properties for B1YMD8

Type Name Position InterPro Accession
conserved_site Translation initiation factor 3, conserved site 72 - 85 IPR019813
domain Translation initiation factor 3, N-terminal 22 - 90 IPR019814
domain Translation initiation factor 3, C-terminal 97 - 183 IPR019815

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mismatch repair complex Any complex formed of proteins that act in mismatch repair.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGIIRELSDS LANRIAAGEV VERPASVVKE LVENALDAGA TQVDVELEEA GMKRITIRDN
70 80 90 100 110 120
GHGFYPEDAE LAFVRHATSK IKDEHDLFRI KTLGFRGEAL ASIASVSKVT LKTKREEQEG
130 140 150 160 170 180
IQLTLDCGRL TDRSAIAMNR GTELTVEQLF FNTPARLKYL KTTHTELAAI TDILNRVAFA
190 200 210 220 230 240
HPDVKLYAVH EGKVLIQTNG SGDVRQALAS VYGHQTIQGT LVATGTTADY QLTCHLVKPE
250 260 270 280 290 300
VTRASKNYIT LILNGRSVKN FALTQAVLNG YHTLLPIGRF PIAVIEVTMD PLLIDVNVHP
310 320 330 340 350 360
AKREVRLSKE AELCQLIQET IRLTLSRQTL IPKVTPQKPK KDPSAQEKLE FSYVAEPVEE
370 380 390 400 410 420
LSSRSVWNYP IPKRTEAGNE HVPSANRIQP PDPSIDMPDE PVPEQTDEPV ATGPKFPHLD
430 440 450 460 470 480
VIGQLHSSYI VCSGADGMYL IDQHAAQERI KYETYKVMFG RPLEQKQQLL LPYTFEIASD
490 500 510 520 530 540
DMRRMDEVLP LLRDVGIELE AFGPQSFIVR EVPTWFPSHR QEETIQELMD EALMKRKVDL
550 560 570 580 590 600
ETYREDAAIM MACKKSIKAN HPLNHEMMRQ LIVDLAKTEM PFTCPHGRPV IIEWTTYELE
KLFKRVT