B1YD09

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta) (Thermoproteus neutrophilus)
KEGG Pathway
tne:Tneu_0733
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1YD09

Entry ID Method Resolution Chain Position Source
AF-B1YD09-F1 Predicted AlphaFoldDB

No variants for B1YD09

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1YD09

No associated diseases with B1YD09

5 regional properties for B1YD09

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 277 - 476 IPR002314
domain Anticodon-binding 498 - 586 IPR004154
domain Aminoacyl-tRNA synthetase, class II 244 - 488 IPR006195
domain Threonyl-tRNA synthetase, editing domain, archaea 1 - 134 IPR015011
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 496 - 585 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRVLYLHTER FSWEVKEPAL DIRDEPVSGG ASNALVVFTT VERGDVPEEG FLRQIARDIV
70 80 90 100 110 120
EVAEKVKASS IVIYPYAHLS NELARPYAAR EIVNKLYEVV KSEFRGEVYK APFGYYKAFE
130 140 150 160 170 180
LKCLGHPLSE LSRSFKPGDS RAEKKAEERR DLYIVITPSG EEHDPAKFNY DGYEDLKILV
190 200 210 220 230 240
EKEVFKRELG GGSEPRYLEY MRKFGFEWEP MSDVGHMRYA PEATLMMELV EDYAYAVAKS
250 260 270 280 290 300
LGIPVFKIRG TNMFKLSERA IESHARLFGE RLYIVESDTD LILRYAACFQ QFAMVKDWVI
310 320 330 340 350 360
SYRQLPFGML EVADSYRLEQ PGETVLLFRL RRFYMPDLHI FTKDLAEAME VTFRLHEAIF
370 380 390 400 410 420
REIGKLGRTY VSLYNVTEDF YKAHRQYLVE LARREGKPIL VRVLPGQKYY WVLNVEFHII
430 440 450 460 470 480
DELGRPREIA TFQIDVGNAQ RFGIKYVDEN NQTRYPVIIH TAILGSVERY LYAVFDTLAR
490 500 510 520 530 540
AEKEGKAPRL PTWLSPVQVR IIPITRDNLK YAVEVADKFE AEGIRVDVDD RDETLSKRIR
550 560 570 580 590 600
DAEVAWVPYI CVVGSKEEAE GVVSVRERGG GQYRVKPEDL IKKIREDVRG YPNRPLYMPR
FLSQRPTRS