B1Y963

PR
Gene name
proS
Protein name
Proline--tRNA ligase
Names
Prolyl-tRNA synthetase, ProRS
Species
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta) (Thermoproteus neutrophilus)
KEGG Pathway
tne:Tneu_1366
EC number
6.1.1.15: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

377-447 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1Y963

Entry ID Method Resolution Chain Position Source
AF-B1Y963-F1 Predicted AlphaFoldDB

No variants for B1Y963

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1Y963

No associated diseases with B1Y963

4 regional properties for B1Y963

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 104 - 274 IPR002314
domain Anticodon-binding 293 - 389 IPR004154
domain Aminoacyl-tRNA synthetase, class II 40 - 286 IPR006195
domain Proline-tRNA ligase, class II, C-terminal 416 - 487 IPR016061

Functions

Description
EC Number 6.1.1.15 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

1 GO annotations of biological process

Name Definition
prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELLRSARPH PKEKLKNVIE WFHWLLREAE LYDVRYPVKG AYVWRPYGMK LRRNVEELIR
70 80 90 100 110 120
RVHDETGHEE VLFPVFIPYE FFGKESQHIR GFEKEVFWVS KGGEGGERLV LRPTSETAIM
130 140 150 160 170 180
PMVKLWIQDY KDLPLRLYQI VSVFRAETKM THPMIRLREI SMFKEAHTVH VDREDAERQV
190 200 210 220 230 240
REAVEIYKRI FDEMCLAYMI NKRPDWDKFA GAEYTIAFDT VLPDGRTLQI GTAHYLGTNF
250 260 270 280 290 300
TRVFEVTYLD ADGTRKLAHT TSYGISERSI AAMLITHGDD GGTTLPPKLA PIQIAVVPIY
310 320 330 340 350 360
YSDEEMPLVM KFVEEVVAAL KGAGLRLHVD DRRDKTPGWK FYYWELKGVP LRLEVGKRDV
370 380 390 400 410 420
EKRQVVVTRR DTLEKYAVAL GELVDAVREL MKAVEDNLRR RAWEELRSKI VKVQSLEEAK
430 440 450 460 470 480
KAIKEGKVVE VPWSGDNQCG MKIQELLGAD ALGIPMDSEA SIGGYDARDL ACGERRAELW
LRLSERY