B1Y3C1

PR
Gene name
pyrD
Protein name
Dihydroorotate dehydrogenase (quinone)
Names
DHOdehase, DHOD, DHODase, Dihydroorotate oxidase
Species
Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
KEGG Pathway
lch:Lcho_1055
EC number
1.3.5.2: With a quinone or related compound as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

63-134 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1Y3C1

Entry ID Method Resolution Chain Position Source
AF-B1Y3C1-F1 Predicted AlphaFoldDB

No variants for B1Y3C1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1Y3C1

No associated diseases with B1Y3C1

2 regional properties for B1Y3C1

Type Name Position InterPro Accession
conserved_site Dihydroorotate dehydrogenase, conserved site 83 - 102 IPR001295
domain Dihydroorotate dehydrogenase domain 50 - 343 IPR005720

Functions

Description
EC Number 1.3.5.2 With a quinone or related compound as acceptor
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
dihydroorotate dehydrogenase activity Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.

2 GO annotations of biological process

Name Definition
'de novo' pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
'de novo' UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALVPYPLTR PFLFGMDPEA AHELTLGSIA RFQNTPLQCL WSQSRIADPV TVAGLRFPNR
70 80 90 100 110 120
IGLAAGLDKN GRCIDGLGAM GFGFIEVGTV TPLGQPGNPK PRMFRLPEKN ALINRLGFNN
130 140 150 160 170 180
EGLASFLANV QRATSFRRNG GLLGLNIGKN AVTPIENAAD DYLIALAGVY PHADYVTVNI
190 200 210 220 230 240
SSPNTKNLRA LQSDAALDAL LGALQTRRLA LATEHGRSVP MFVKIAPDLD EAQVRVIAAT
250 260 270 280 290 300
LRHNGIDGVI ATNTTLARDA VAGLAHADEA GGLSGAPVLA ASNRVIAQLR AELGGAYPII
310 320 330 340
GVGGVLSGAD ARSKRAAGAD LVQVYTGLIY RGPALVPECA RALRG