B1Y1G9

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
KEGG Pathway
lch:Lcho_2001
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

324-474 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1Y1G9

Entry ID Method Resolution Chain Position Source
AF-B1Y1G9-F1 Predicted AlphaFoldDB

No variants for B1Y1G9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1Y1G9

No associated diseases with B1Y1G9

4 regional properties for B1Y1G9

Type Name Position InterPro Accession
domain DHHA1 domain 735 - 867 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 654 - 696 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 556 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 709 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKASEIRSTF LKFFESKGHQ IVGSSPVVPG DDPTLLFTNA GMNQFKDVFL GFDKRPYSRA
70 80 90 100 110 120
TTSQKCIRAG GKHNDLDNVG YTARHHTFFE MLGNFSFGDY FKHDAISYAW ELLTEHFKLP
130 140 150 160 170 180
KDKLWVTVYS EDDEAYEIWN KVVGVPAERI VRIGDNKGAR YMSDNFWMMG DTGPCGPCTE
190 200 210 220 230 240
IFFDHGEGIP GGPPGSPDED GDRYIEIWNN VFMQFNRTED GVMHKLPKPS VDTGMGLERI
250 260 270 280 290 300
TAVLQHVHSN YEIDLFVALL AAAKAAVESA GGKDVDPESP SLKVIADHIR ACSFTIVDGV
310 320 330 340 350 360
IPGNEGRGYV LRRIARRAIR HGYKLGARTP FFHKIVAELV AQMGEAYPEL RAAQARVTEV
370 380 390 400 410 420
LKQEEERFFQ TIQHGMEILE HALAGGTKQV DGETAFKLHD TYGFPVDLTA DVCRERGVTV
430 440 450 460 470 480
DQAGFDAAME HQRSQARAAG KFKMAAGLAY SGAPTAFHGY EHLVCETSKV VAIYVDGTPV
490 500 510 520 530 540
DAAQAGDDAA IVLDHTPFYA ESGGQAGDSG ELRNGSTRVV VADTFKIQAD VFGHHGRIVE
550 560 570 580 590 600
GSVKVGDSFV AKVDAELRAK TVRNHSATHL MHKALREVLG AHVQQKGSLV NAERTRFDFA
610 620 630 640 650 660
HNAPVSDAQI RQVEAIVNAE ILANAAASAQ VMALDDAQKS GAMMLFGEKY GETVRVLSIG
670 680 690 700 710 720
SSKELCGGTH VKATGDIGLF KVVAESGVAA GIRRIEAITG DNALAYLQSL ESTVNGVASA
730 740 750 760 770 780
LKSAVPEVPA RISGLQDQVR ALEKELAALK GKLASSQGDS LLAQTVDING LKVLAVVLEG
790 800 810 820 830 840
ADAATLRTTM DQLKNKLKTA AIVLAAVDGG KVQLAAGVTA DSTAKVKAGE LVNFVAQQVG
850 860 870
GKGGGKPDMA MAGGTDPSKL AAALASVPGW VGERV