B1XYZ3

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
KEGG Pathway
lch:Lcho_1745
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

94-172 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1XYZ3

Entry ID Method Resolution Chain Position Source
AF-B1XYZ3-F1 Predicted AlphaFoldDB

No variants for B1XYZ3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1XYZ3

No associated diseases with B1XYZ3

7 regional properties for B1XYZ3

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 322 - 532 IPR002314
domain TGS 1 - 65 IPR004095
domain Anticodon-binding 544 - 632 IPR004154
domain Aminoacyl-tRNA synthetase, class II 265 - 537 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 173 - 222 IPR012947
domain Threonine-tRNA ligase catalytic core domain 245 - 542 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 542 - 631 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIAIQLPDGS RREFDGPVTV AEVAASIGAG LAKAALAGRI GTGDAARLVD TSHRIEADEA
70 80 90 100 110 120
LSIITAKDAA GLDVIRHSTA HLLAYAVKEL FPDAQVTIGP TIENGFFYDF SYKRPFTPDD
130 140 150 160 170 180
LAAIEKKMGD LAAKDEPVVR SVMPRDEAVS YFKSIGEAYK AEIIESIPAD QAVSLYAEGK
190 200 210 220 230 240
FTDLCRGPHV PSTGKLKFFK LMKVAGAYWR GDHRNEMLQR IYGTAWATKD DLQKYLVMLE
250 260 270 280 290 300
EAEKRDHRKL GRELDLFHID EHAPGVVFWH PKGWTVWQQV EQYMRRVYRD NGYQEVKGPQ
310 320 330 340 350 360
ILDKGLWEKT GHWDKYRDNM FTTESEKRDY ALKPMNCPGH ILIFKQGIKS YRDLPLRYGE
370 380 390 400 410 420
FGQCHRNEPS GGLHGIMRVR GFTQDDGHIF CTEDQILPEC DAFTTLLQKV YADFGFTEIL
430 440 450 460 470 480
YKVATRPEKR IGSDELWDKA EAALIASLRN SGCEFEISPG EGAFYGPKVE YTLKDALGRH
490 500 510 520 530 540
WQCGTIQVDF SLPERLDAEY VAESGERLHP VMLHRAILGS LERFIGILIE EHAGALPFWL
550 560 570 580 590 600
APTQVSVLNI TDGQADYARD VARSLQKQGL RVALDLRNEK ITYKIREHSL QKVPYLIVVG
610 620 630
DKERASGAVA VRARGNQDLG VMALEAFSQK LAAELAT