B1XYW5

PR
Gene name
proS
Protein name
Proline--tRNA ligase
Names
Prolyl-tRNA synthetase, ProRS
Species
Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
KEGG Pathway
lch:Lcho_0574
EC number
6.1.1.15: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1XYW5

Entry ID Method Resolution Chain Position Source
AF-B1XYW5-F1 Predicted AlphaFoldDB

No variants for B1XYW5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1XYW5

No associated diseases with B1XYW5

6 regional properties for B1XYW5

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 95 - 455 IPR002314
domain Anticodon-binding 474 - 561 IPR004154
domain Aminoacyl-tRNA synthetase, class II 33 - 464 IPR006195
domain YbaK/aminoacyl-tRNA synthetase-associated domain 257 - 375 IPR007214
domain Prokaryote proline-tRNA ligase core domain 17 - 454 IPR033730
domain Proline--tRNA ligase, anticodon binding domain 469 - 560 IPR044140

Functions

Description
EC Number 6.1.1.15 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

1 GO annotations of biological process

Name Definition
prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKASQFFIAT LKEAPADAEV KSHQLMMRAG MIKRLGAGIY NYMPMGLRVI RKVEAIIREE
70 80 90 100 110 120
MNRAGAVELL MPVVQPAELW QETGRFDKMG PELLRVKDRH DRDFIIQPTS EEVVTDIARQ
130 140 150 160 170 180
ELRSYKQLPK NFYHIQTKFR DERRPRFGIM RGREFTMKDA YSFDRDAASA ARSYDAMFAA
190 200 210 220 230 240
YKRIFDRFGL QYRAVAADTG AIGGDLSHEF QVIADTGEDA IVYCPTSDYA ANIELAEAVS
250 260 270 280 290 300
LIAERGAATE SMAKTPTPGK STCADVAQLL NLPLARTVKS LVLATDELNE AGDVAKTTVW
310 320 330 340 350 360
LLLVRGDHDM NEVKVGKVDG LKAGFRFATV AEIESHFGCK PGYLGPIGLK KPVKVIADRT
370 380 390 400 410 420
VAQMADFICG ANEIDFHLTG INWGRDLPEP DAVADIRNVV EGDPSPDGQG VLAIQRGIEV
430 440 450 460 470 480
GHVFFLGTKY SKAMNATYLD ENGKPQFMEM GCYGIGVTRI LGAAIEQKHD ARGILWPDAI
490 500 510 520 530 540
APFTVVVCPI GYDRSAEVKA AADALHDELQ AAGIDVMLDD RGERPGAMFA DWELIGVPHR
550 560 570 580
VVISDRGLKA GQVEYQGRCD EAASTVPAAE VAAFVKGRLR S