B1XSP4

PR
Gene name
rpoC
Protein name
DNA-directed RNA polymerase subunit beta'
Names
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'
Species
Polynucleobacter necessarius subsp necessarius (strain STIR1)
KEGG Pathway
pne:Pnec_0043
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

287-357 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1XSP4

Entry ID Method Resolution Chain Position Source
AF-B1XSP4-F1 Predicted AlphaFoldDB

No variants for B1XSP4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1XSP4

No associated diseases with B1XSP4

7 regional properties for B1XSP4

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 348 - 389 IPR000722-1
domain RNA polymerase, alpha subunit 395 - 489 IPR000722-2
domain RNA polymerase, N-terminal 239 - 518 IPR006592
domain RNA polymerase Rpb1, domain 3 493 - 653 IPR007066
domain RNA polymerase Rpb1, domain 1 16 - 346 IPR007080
domain RNA polymerase Rpb1, domain 5 775 - 1325 IPR007081
domain RNA polymerase Rpb1, domain 4 683 - 772 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
magnesium ion binding Binding to a magnesium (Mg) ion.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKALLDLFKQ TQGDEQFDVI KIGLASPEKI RSWSFGEVRK PEAINYRTFK PERDGLFCAK
70 80 90 100 110 120
IFGPTKDYEC LCGKYKRLKF RGIICEKCGV EVTLAKVRRE RMGHIELAAP VAHIWFLKSL
130 140 150 160 170 180
PSRLGMVLDM TLRDIERVLY FEAYVVVDPG MTPEGAMKRG QIMSEDEYIA KTEEYGDGVF
190 200 210 220 230 240
TAIMGAEGIR DLLRSIDIDR EVETIRADLK ATGSDAKIKK YAKRLKVLEA FQTSGIKPDW
250 260 270 280 290 300
MIMEVLPVLP PELRPLVPLD GGRFATSDLN DLYRRVINRN NRLKRLLELR APEIIVRNEK
310 320 330 340 350 360
RMLQEAVDSL LDNGRRGKAM TGANKRPLKS LAEMIKGKSG RFRQNLLGKR VDYSGRSVIV
370 380 390 400 410 420
VGPTLKLHQC GLPKLMALEL FKPFIFNKLE TLGIATTIKA AKKEVESQTP IVWDILEEVI
430 440 450 460 470 480
REHPIMLNRA PTLHRLGIQA FEPMLIEGKA IQLHPLVCAA FNADFDGDQM AVHVPLSLEA
490 500 510 520 530 540
QMEARTLMLA SNNVLFPANG EPSIVPSQDV VLGLYYATRD KINGKGEGMV FANITEVVRA
550 560 570 580 590 600
YEAGQVELAS RVAVRITEYE IVDKKAEGDA RFAGKTKIYQ TSVGRAILSE ILPKGMSFEE
610 620 630 640 650 660
INKPLKKKEI SRLINTSFRK CGLRETVIFA DRLLQSGFRL ATNAGISVAI DDMLIPTSKE
670 680 690 700 710 720
RIITEASTKV KEYDKQFMSG LVTNQERYNN VVDIWGAAGD QVGKAMMDEL SHVDVLDRNG
730 740 750 760 770 780
KTVRQESFNS IYMMADSGAR GSAAQIRQLA GMRGLMAKPD GSIIETPITA NFREGLNVLQ
790 800 810 820 830 840
YFISTHGARK GLADTALKTA NSGYLTRRLC DVTQDLVVIE EDCGATTGVT MKALVEGGEI
850 860 870 880 890 900
IEALRDRILG RVCIGDIVHP DTQEVIVPND TLLDEDHVDQ IVALGIDEVK VRTVLSCLTR
910 920 930 940 950 960
FGLCAKCYGR DLGRGGLVNV GEAVGVIAAQ SIGEPGTQLT MRTFHIGGAA SRALVASNIE
970 980 990 1000 1010 1020
AKSNGALKFS GTMRVVKNSR GEQIVISRSG EALIVDENGR ERERHKVPYG ATLLLKEDAA
1030 1040 1050 1060 1070 1080
VKAGASLATW DPLTRPIISE YAGIARFDNV EEGVTVAKQV DEITGLSTLV VIDGKRRSAA
1090 1100 1110 1120 1130 1140
SKGVRPVINL IDDKGNDVMI AGTDHPVNIG LQVGALITVK DGQKVEVGEV LARIPIESQK
1150 1160 1170 1180 1190 1200
TRDITGGLPR VAELFEARSP KDAAVLAKVT GTVSFGKETK GKQRLVITDM DGEANEFLIP
1210 1220 1230 1240 1250 1260
KEKQVLVHDG QVVNKGEMIV EGPADPHDIL TLKGIEELAI YIVDEVQDVY RLQGVKINDK
1270 1280 1290 1300 1310 1320
HIEVIVRQML RRVQVTDPGD TSFITGEQVE RSKLYDENDR VIAEGKHPAQ FDNVLLGITK
1330 1340 1350 1360 1370 1380
ASLSTDSFIS AASFQETTRV LTEAAIMGKT DTLRGLKENV IIGRLIPAGT GLSYRRARKV
1390 1400 1410
REQFERDRAQ MIAAEEEAMA NMPVEIEAEV VALTGEADPS