B1WYQ5

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Crocosphaera subtropica (strain ATCC 51142 / BH68) (Cyanothece sp. (strain ATCC 51142))
KEGG Pathway
cyt:cce_1722
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

387-468 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1WYQ5

Entry ID Method Resolution Chain Position Source
AF-B1WYQ5-F1 Predicted AlphaFoldDB

No variants for B1WYQ5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1WYQ5

No associated diseases with B1WYQ5

4 regional properties for B1WYQ5

Type Name Position InterPro Accession
domain DHHA1 domain 735 - 873 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 653 - 696 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 12 - 554 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 8 - 709 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTTAPFLTG NQIRDRFLQF YAQHNHQILP SASLVPEDPT VLLTIAGMLP FKPIFLGQKQ
70 80 90 100 110 120
PDFPRATTSQ KCIRTNDIEN VGRTARHHTF FEMLGNFSFG DYFKEQAIKW AWELSTKVYR
130 140 150 160 170 180
LPPENIVVSV FEKDDEAFKL WEEMIGIPPQ RIKRMGEKDN FWKAGPTGPC GPCSELYYDF
190 200 210 220 230 240
HPELGEDNID LEDDSRFIEF YNLVFMEYNR DAEGNLAPLQ NKNIDTGMGL ERMAQILQKV
250 260 270 280 290 300
PNNYETDLIF PIIETAANIA NIDYQKATEK TKVSLKVIGD HVRSVVHMIA DGITASNTDR
310 320 330 340 350 360
GYVLRRLIRR VVRHGRLIGI EGQFIKQVAE TAIELSENAY PQVRERESFI KGELEREETA
370 380 390 400 410 420
FLKTLERGEK LLAEIIEKTE TQGQISGVDA FTLYDTYGFP LELTQEIAEE SNLTVNIEEF
430 440 450 460 470 480
EAEMRQQQER SKAAHETIDL TVQGSLDKLA EHIHPTAFLG YTDLQLTAKV EAVLIQGKTV
490 500 510 520 530 540
DTAEAGSEVQ IVLDQTPFYG ESGGQIGDRG FLTGENLVIR VEDVQKESGI FVHFGRVERG
550 560 570 580 590 600
SVSVNDQVTA TIDRACRRQV QANHTATHLL QAALKKVVDK SISQAGSLVA FDRLRFDFNC
610 620 630 640 650 660
PRAVTSEELQ EIEDLINTWI AEAHETEIAV MPIETAKEKG AIAMFGEKYG SEVRVIDVPG
670 680 690 700 710 720
VSMELCGGTH VKNTAEIGLF KIMSESGISS GVRRIEAVAG PAVLEYLKVR ETVVKDLCDR
730 740 750 760 770 780
FKIKPEEISD RITTLQSELK TTQKELEAVK QDLAVAKSDQ LLTEAESIGE FKLLVSDMGE
790 800 810 820 830 840
MDAKALQTAA ERLQQKLGEG AVILGSIPSE GKVSLVAAFS KKVNQEKQLQ AGKFIGQIAK
850 860 870
ICGGGGGGRP NLAQAGGREP SKLSEALLTA KEQLTESLK