B1WVA3

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Crocosphaera subtropica (strain ATCC 51142 / BH68) (Cyanothece sp. (strain ATCC 51142))
KEGG Pathway
cyt:cce_4545
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1WVA3

Entry ID Method Resolution Chain Position Source
AF-B1WVA3-F1 Predicted AlphaFoldDB

No variants for B1WVA3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1WVA3

No associated diseases with B1WVA3

1 regional properties for B1WVA3

Type Name Position InterPro Accession
domain Membrane fusion protein, biotin-lipoyl like domain 87 - 135 IPR039562

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDPKSYKDT VNLPKTNFSM RANAVKREPE LQKFWADNQI YEKLSQENPE EVFVLHDGPP
70 80 90 100 110 120
YANGSLHMGH ALNKTLKDII NKYKLLRGYK VRYVPGWDCH GLPIELKVLQ SMKSKEREGL
130 140 150 160 170 180
TPLKLRHKAR DFALKTQEEQ AKGFKRFGVW GDWENPYLTL TPEYEAAQIG VFGEMALKGY
190 200 210 220 230 240
IYRGLKPVHW SPSSQTALAE AELEYPEGHT SRSIFAAFPI IKASKDTEEI LQPFLNKLGV
250 260 270 280 290 300
AIWTTTPWTL PGNLAVALNP DLNYAVVEQN SDVCNYQYLI VAADLVERLS TTFETELTVK
310 320 330 340 350 360
ATLPGKALEH TIYRHPLYDR ESEILIGGDY VTTESGTGLV HTAPGHGQED YMVGQRYGLG
370 380 390 400 410 420
ILSPVDAKGN FTEEARQFAG LNVLKDANEV IINELKEKGS LLKEEAYQHK YPYDWRTKKP
430 440 450 460 470 480
TIFRATEQWF ASVKGFRDAA LTAIKTVQWI PAQGENRITP MVSDRSDWCI SRQRSWGLPI
490 500 510 520 530 540
PVFYDEETNE PLLTEETIKH IQTIFAEKGS DAWWEMSIEA LLPDQYKADA HKYRKGTDTM
550 560 570 580 590 600
DVWFDSGSSW ASVAKQRPEL KYPADIYLEG SDQHRGWFQS SLLTSVAVNE IAPYKTVLTH
610 620 630 640 650 660
GFVLDEKGHK MSKSLGNIVD PNVIINGGKN QKQEPPYGAD VLRLWVSSVD YSSDVPIGKT
670 680 690 700 710 720
ILKQLSDIYR KIRNTARFLL GNLHDFDPKK DTVSYEELPE LDRYMLHRIT EVFTEVTDAF
730 740 750 760 770 780
ETYQFFRFFQ TVQNFCVVDL SNFYLDIAKD RLYISHPESI RRRSCQTVLA IAIENLAKAI
790 800 810 820 830 840
APVLCHMAED IWQFLPYETP YKSVFTAGWV KTSKQWENSE LSASWAKIRG IRNEVNNALE
850 860 870 880 890 900
LARKEKAIGS SLDAKVLLYV PEQNLRQQLE KFNPADSLTG NHVDELRYFV LASQVELVDS
910 920 930 940 950
LDSIKNADYH SESDLVSVGV IKAEGEKCDR CWNYSTKVGE FKDDPTICER CNAALVGDF