B1WAX6

PR
Gene name
tigar
Protein name
Fructose-2,6-bisphosphatase TIGAR
Names
TP53-induced glycolysis and apoptosis regulator
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:100145723
EC number
3.1.3.46: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

124-205 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1WAX6

Entry ID Method Resolution Chain Position Source
AF-B1WAX6-F1 Predicted AlphaFoldDB

No variants for B1WAX6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1WAX6

No associated diseases with B1WAX6

2 regional properties for B1WAX6

Type Name Position InterPro Accession
conserved_site Glycoside hydrolase, family 35, conserved site 192 - 204 IPR019801
domain Glycoside hydrolase 35, catalytic domain 56 - 365 IPR031330

Functions

Description
EC Number 3.1.3.46 Phosphoric monoester hydrolases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
bisphosphoglycerate 2-phosphatase activity Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate.
fructose-2,6-bisphosphate 2-phosphatase activity Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.

8 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
fructose 1,6-bisphosphate metabolic process The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis.
fructose 2,6-bisphosphate metabolic process The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
negative regulation of glycolytic process Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
negative regulation of programmed cell death Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
positive regulation of DNA repair Any process that activates or increases the frequency, rate or extent of DNA repair.
regulation of pentose-phosphate shunt Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T014 BPGM Bisphosphoglycerate mutase Bos taurus (Bovine) PR
10 20 30 40 50 60
MARFALTIVR HGETRYNKEK LLQGQGIDEP LSEIGFKQAD AVGRFLSNVR FTHVFSSDLI
70 80 90 100 110 120
RAKQTACAIM ENNKISEDIK IIYDRRLRER KYGDAEGRPL SELKVMAKKA GDQCPSYTPP
130 140 150 160 170 180
GGETLEQVRA RAKDFFEYLC RLVLEESSAK EQSELGASGM GGVTSADLGP FVNHNKEPAE
190 200 210 220 230 240
LGESRDVTVH ASVLLVSHGA YMRNWIKYLV EDLQFTFPPE LKKSRELPVS PNTGISHFIV
250 260 270
TVSSATPRKP EIQCVCINLH SHLSDINADT SHYQV