B1MXP8

PR
Gene name
alaS (LCK_00467)
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Leuconostoc citreum (strain KM20)
KEGG Pathway
lci:LCK_00467
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

32-107 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1MXP8

Entry ID Method Resolution Chain Position Source
AF-B1MXP8-F1 Predicted AlphaFoldDB

No variants for B1MXP8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1MXP8

No associated diseases with B1MXP8

4 regional properties for B1MXP8

Type Name Position InterPro Accession
domain DHHA1 domain 751 - 889 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 670 - 713 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 570 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 726 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKELTSSEVR QMFLDFFASK GHEIVPSKNL IPQDDPTLLW INSGVATLKK YFDGSVIPKN
70 80 90 100 110 120
PRITNAQKAI RTNDIENVGK TARHHTLFEM MGNFSVGDYF KAEVIPWAWE LLTSPEWYGL
130 140 150 160 170 180
DKDLLYVTVY PKDQEAKKIW LEKTDLPEGH IYEVEDNFWD IGEGPSGPDS EIFFDRGPAF
190 200 210 220 230 240
QNLPDNDPEM YPGGENERYL EIWNIVFSQF NHLPGLTDNA QYPELPHKNI DTGMGLERLV
250 260 270 280 290 300
SVFQNGRTNF DTDLFLPIIR ATEKMSPDYT YDATKDSESN TSFKVIADHI RAITFAIGDG
310 320 330 340 350 360
ALPANEGRGY VIRRLLRRAV LHGQKLGIQG EFLTKLVPIV AEIMQSYYPE IADNTEKIQK
370 380 390 400 410 420
TIAAEEKRFN ATLTGGLSLL NDVIAKAKAS GQQVISGADA FKLSDTYGFP LELTQEQAAD
430 440 450 460 470 480
EGLTVDVVGF NDALQAQRTR ARAARSNDKS MGVQNAVLTD LKVPSDYVGW SETEVSNAAI
490 500 510 520 530 540
VAIIGHDNQG VDALLANAEP GDSVQLVFDK TPFYAEMGGQ VADQGEVLNK QGEVVARVTD
550 560 570 580 590 600
TQSAPNGQHV HTVEVVTSFK LGDQVALKVN LARHVAISKN HTATHLLDQT LRNVIGGDVH
610 620 630 640 650 660
QAGSLVEPEY LRFDFTHEGP VSEQNLEKIE TMVNQVIANN LPITWVETDI ESAKKMGAVA
670 680 690 700 710 720
VFGEKYGDVV RVVSIGDFNK EFDGGTHAQT TAELGLFKIV SESGIGAGVR RIEAVTGLAA
730 740 750 760 770 780
LSQFKAEEQA LKVIADSLKA QKLTDAPAKV EDLQVEIKTL QRHLTSVEAQ LANAAAQDVF
790 800 810 820 830 840
KDVKTQNGYQ YITAQLQVSG MDGLRQVVDT WRENYPSDVL VLATHVDDKV SLIVAASPEA
850 860 870 880 890
NKKGFKAGDL IKAIAPKIGG GGGGRPDMAQ AGGKNPAGIN DAFSAVSTFL DELA