B1MIP8
Gene name |
thiC |
Protein name |
Phosphomethylpyrimidine synthase |
Names |
Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC |
Species |
Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) (Mycobacterium abscessus) |
KEGG Pathway |
mab:MAB_4196 |
EC number |
4.1.99.17: Other carbon-carbon lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B1MIP8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B1MIP8-F1 | Predicted | AlphaFoldDB |
No variants for B1MIP8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B1MIP8 | |||||
No associated diseases with B1MIP8
1 regional properties for B1MIP8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ThiC-associated domain | 19 - 80 | IPR025747 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.99.17 | Other carbon-carbon lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| carbon-carbon lyase activity | Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| thiamine biosynthetic process | The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. |
| thiamine diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTPSSRSQA | PETVTTGPIQ | GSEKIYQELP | NGLRVPQRRV | NLTNGEYLDL | YDTSGPYTDT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NAVIDLHKGL | PPRAGIVTDR | GTQLQRARAG | EITAEMEFIA | VREGVPAELV | RTEVAAGRAV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IPANHKHPES | EPMIIGKAFG | VKINANIGNS | AVTSSIAEEV | EKMVWAIRWG | ADNIMDLSTG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KDIHQTREWI | LRNSPVPVGT | VPIYQALEKT | NGDPAALTWE | LYRDTVIEQA | EQGVDYMTVH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AGVLLRYVPL | TAKRVTGIVS | RGGSIMAAWC | LAHHRESFLY | THFEELCEIL | ARYDVTFSLG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DGLRPGSIAD | ANDEAQFAEL | RTLGELTKIA | KSHGVQVMIE | GPGHVPMHKI | VENVKLEEEL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CEEAPFYTLG | PLATDIAPAY | DHITSAIGAA | IIAQAGTAML | CYVTPKEHLG | LPDRKDVKDG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VIAYKIAAHS | ADLAKGHPRA | QLRDNALSKA | RFEFRWEDQF | NLSLDPDTAR | EFHDETLPAE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PAKTAHFCSM | CGPKFCSMRI | TADIREFAAE | NGLETQEDID | AMLARGMEEK | SAEFAEHGNR |
| VYLPIA |