B1MB03

PR
Gene name
argH
Protein name
Argininosuccinate lyase
Names
ASAL, Arginosuccinase
Species
Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) (Mycobacterium abscessus)
KEGG Pathway
mab:MAB_2343
EC number
4.3.2.1: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

404-473 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1MB03

Entry ID Method Resolution Chain Position Source
AF-B1MB03-F1 Predicted AlphaFoldDB

No variants for B1MB03

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1MB03

No associated diseases with B1MB03

3 regional properties for B1MB03

Type Name Position InterPro Accession
conserved_site Fumarate lyase, conserved site 281 - 290 IPR020557
domain Fumarate lyase, N-terminal 19 - 306 IPR022761
domain Argininosuccinate lyase, C-terminal 369 - 437 IPR029419

Functions

Description
EC Number 4.3.2.1 Lyases acting on amides, amidines, etc
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.

1 GO annotations of biological process

Name Definition
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTNEGSLWG GRFAGGPAPA LAALSKSTHF DWALAPYDIQ ASVAHARVLR KAGLLTDEQL
70 80 90 100 110 120
GALVEGLEQL GRDVASGVFV PADTDEDVHG ALERGLIERV GPDIGGRLRA GRSRNDQVAT
130 140 150 160 170 180
LFRMWLRDAA GRISEGVLDV VQALADQAGA HPDAIMPGKT HLQAAQPVLL AHHLLAHAQP
190 200 210 220 230 240
LLRDVDRLVD WDRRTAVSPY GAGALAGSSL GLDPDAIALD LGFTAAADNS IDATSSRDFA
250 260 270 280 290 300
AEAGFVFAMI GIDLSRLSED IILWGTTEFG YVTLDDSWST GSSIMPQKKN PDIAELARGK
310 320 330 340 350 360
TGRLIGNLTG LLATLKAQPL AYNRDLQEDK EPLFDSVSQL ELLLPAMAGL VATLRFHTER
370 380 390 400 410 420
MAQLAPAGFT LATDLAEWMV RQGIPFRVAH EAAGEAVRVA EARGVGLEDL TDEEFAAIHP
430 440 450 460 470
ELTGDVRAVL TTAGSVASRD ARGGTAPERV AEQRELVLAR LNVLRGQNGR HPG