B1L5G0

PR
Gene name
serS
Protein name
Serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Korarchaeum cryptofilum (strain OPF8)
KEGG Pathway
kcr:Kcr_0943
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

24-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1L5G0

Entry ID Method Resolution Chain Position Source
AF-B1L5G0-F1 Predicted AlphaFoldDB

No variants for B1L5G0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1L5G0

No associated diseases with B1L5G0

4 regional properties for B1L5G0

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 243 - 419 IPR002314
domain Aminoacyl-tRNA synthetase, class II 195 - 429 IPR006195
domain Serine-tRNA synthetase, type1, N-terminal 7 - 106 IPR015866
domain Serine-tRNA ligase catalytic core domain 121 - 436 IPR033729

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
tRNA binding Binding to a transfer RNA.

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSWSVLEALR KDPEILRENL RRRFLPLDML ERAIELDRKW REAVTELNSL RERRNEINRS
70 80 90 100 110 120
IPRADPGERE ELIRKAKEIG EEIERLEDVL EKLSQERDSI LMSMPALIDD SVPIGPNEDY
130 140 150 160 170 180
NKPIRFWGKP KVPRSKLDSF MEQTRGFNVE YELIDWEPLG HADELEVMLK QVDTVKAGQL
190 200 210 220 230 240
AGSRFFYLFK DIVWLEQALI LFALDKISRK GFIPVIPPYM MRRDYYLGVV DLNTFEDSIY
250 260 270 280 290 300
KVEGEDLYLI ATSEHPLVAM HAGDTFTEDE LPRLYVGLSP CFRKEAGTHG KDTKGIFRVH
310 320 330 340 350 360
QFTKVEQIVF SKPEESKYWH ERLIENAEEI YRELEIPYRI VNIASGDLGA SAAKKYDLEG
370 380 390 400 410 420
WFPAQGKYRE LVSCSNCVDW QSYRLRIKLD RKGRREFVHT LNSTALATTR TISAIVENHQ
430 440 450
REDGSVRIPK ALRKYLEIFE QAPKEEIVPI EKILKE