B1L5A4
Gene name |
ctaB |
Protein name |
Protoheme IX farnesyltransferase |
Names |
Heme B farnesyltransferase, Heme O synthase |
Species |
Korarchaeum cryptofilum (strain OPF8) |
KEGG Pathway |
kcr:Kcr_0887 |
EC number |
2.5.1.141: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B1L5A4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B1L5A4-F1 | Predicted | AlphaFoldDB |
No variants for B1L5A4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B1L5A4 | |||||
No associated diseases with B1L5A4
No regional properties for B1L5A4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for B1L5A4 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.141 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| farnesyltranstransferase activity | Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. |
| protoheme IX farnesyltransferase activity | Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| heme biosynthetic process | The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. |
| heme O biosynthetic process | The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQVEVFKVKL | SDLLCLTKPK | QTFLLLLTSI | FTYVGAGGMR | LDALLLLTAA | MLLSISGTTS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VNMALDADID | AMMPRTKDRP | VPSGRVSRVE | ALSFGLLLFI | VGLGLSYLIN | PWTAFATSLG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MAFDILVYTM | WTKRRTPLSI | IFGGVAGAAP | SLAGWAAARG | SIELQAIMIA | LITILWIPSH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IWYISIYYLD | DYAAARVPMA | PVVWGIERTS | KLIVASNVLM | IILQLLLFLM | GPLGPIFLVL |
| 250 | 260 | 270 | 280 | 290 | |
| SLPITLRFLI | HSIRYARSPS | RGEARRMYKV | ASPVEGVIFL | AIALDGIFRI | LWSS |