B1KZ37
Gene name |
cfr |
Protein name |
Ribosomal RNA large subunit methyltransferase Cfr |
Names |
23S rRNA (adenine(2503)-C(8))-methyltransferase, 23S rRNA m8A2503 methyltransferase |
Species |
Clostridium botulinum (strain Loch Maree / Type A3) |
KEGG Pathway |
cbl:CLK_2251 |
EC number |
2.1.1.224: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B1KZ37
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B1KZ37-F1 | Predicted | AlphaFoldDB |
No variants for B1KZ37
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B1KZ37 | |||||
No associated diseases with B1KZ37
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.224 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| metal ion binding | Binding to a metal ion. |
| rRNA (adenine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine. |
| rRNA binding | Binding to a ribosomal RNA. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| response to antibiotic | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. |
| rRNA base methylation | The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKQTKTKYGK | MKQMVSNLKL | PDYRYEQLTK | AIFHQRIDNF | DDIHILPKAL | RMSLVNEFGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NVSSVIPVFS | QDSKQARKLL | FELTDGERIE | AVGLKYKQGW | ESFCISSQCG | CGFGCRFCAT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GSAGFKRNLT | ADEITDQLLY | FYFNNHRLNS | ISFMGMGEAF | ANPELFDAVK | ILTDQNLFGL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SQRRITISTI | GIIPGIQRLT | KKFPQVNLAF | SLHSPFESQR | SDLMPINKRF | PLNEVMKTLD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EHIIHTGRRV | FIAYIMLEGI | NDSKEHAEAV | VGLLKNRGSW | EHLYHIDLIP | YNSTDKTTFK |
| 310 | 320 | 330 | 340 | ||
| FQSSSAIKQF | CSTLKKAGIS | ATVRTQFGSE | ISAACGQLCY | ENEL |