B1KE36

PR
Gene name
glnE
Protein name
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
Names
ATP:glutamine synthetase adenylyltransferase, ATase
Species
Shewanella woodyi (strain ATCC 51908 / MS32)
KEGG Pathway
swd:Swoo_0727
EC number
2.7.7.42: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

457-529 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1KE36

Entry ID Method Resolution Chain Position Source
AF-B1KE36-F1 Predicted AlphaFoldDB

No variants for B1KE36

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1KE36

No associated diseases with B1KE36

4 regional properties for B1KE36

Type Name Position InterPro Accession
domain Glutamate-ammonia ligase adenylyltransferase, repeated domain 41 - 276 IPR005190-1
domain Glutamate-ammonia ligase adenylyltransferase, repeated domain 558 - 813 IPR005190-2
domain PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase 307 - 443 IPR013546-1
domain PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase 835 - 922 IPR013546-2

Functions

Description
EC Number 2.7.7.42 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
[glutamate-ammonia-ligase] adenylyltransferase activity Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)].
[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase Catalysis of the reaction: adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = AMP + [L-glutamate:ammonia ligase (ADP-forming)].
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.

2 GO annotations of biological process

Name Definition
metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
regulation of glutamine family amino acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MENISNKPLS AIISEVADRY WQRINDVFPE LANELTKEQG EELYRIMGLS DFIADQLCRH
70 80 90 100 110 120
PQWILSLFNG ELNNLSRSEF DKDLHGLLSE CQSEDEANRV LRCYRNKQMV RLAWRDFLGY
130 140 150 160 170 180
ASLENSLLDL SALAEALIIS ARDWLYIQAC KQYGTPMDSE GNPQPLIILG MGKLGGRELN
190 200 210 220 230 240
FSSDIDLIFT FPEHGETQGG RRAIENQQFF IRMGQRLVNM LHQVTVDGFV YRVDMRLRPY
250 260 270 280 290 300
GESGPLVVSF SGLEDYYQEQ GRDWERYAMV KARALGPWTA FSDELHSMLR PFVYRRYIDF
310 320 330 340 350 360
SAIESLRKMK QLITQEVRRR QLTDNIKLGA GGIREVEFVV QSFQLIRGGR EPSLRQQSLF
370 380 390 400 410 420
AAIDTLYQLG QLEYLAVDEL KQSYLLLRRV ENLLQGIGDQ QTQTLPDSGL NWYRLCHCMG
430 440 450 460 470 480
MASEAELRTH IESAMSKIHR HFIETVGGRT QDEGADLWTQ QLWIAYEDDD AQTLIKEQMI
490 500 510 520 530 540
DDPELWPQLK SWRETVANRS IGPRGRDTLD KLMPWLLREF TNLPTPSDAL NSVSKVIDQI
550 560 570 580 590 600
LTRTTYLELL YENPGARQQL VSLCCASPWI AAQLAKFPML LDELIDPTQL YDTTSLDDYG
610 620 630 640 650 660
SELRQYLLRV PEEDMEQQME ALRQFKLSQQ LKIAAADVTG VLPVSQVSDH LTLLSEAIIE
670 680 690 700 710 720
QVVMQAWQQV TARHGVPAYL EEGVTGFAVI GYGKAGGIEL GYGSDLDLVF LHSFSREKYP
730 740 750 760 770 780
DQGETDGDRP IEVGHFYLKL AQRILHLFST RTTSGELYEV DMRLRPSGAS GLLVSEIEYF
790 800 810 820 830 840
GEYQREEAWT WEHQALVRAR FMFGSNGLSS RFSELRSEVL QLARDGSDLA KAVRDMRTKM
850 860 870 880 890 900
RDHLLKVKTG HFDLKQSAGG IADIEFIAQY LVLANANQHN ELSFWSDNIR IFTGLGELGI
910 920 930 940 950
LAHADVESLI QAYLFLRDES HRQTLQQKPG ELPLDLVAEH ANRVMDIYQR ILVD