B1IS70

PR
Gene name
hpcH
Protein name
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Names
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, HHED aldolase, 4-hydroxy-2-ketoheptane-1,7-dioate aldolase, HKHD aldolase
Species
Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)
KEGG Pathway
ecl:EcolC_3707
EC number
4.1.2.52: Aldehyde-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

217-262 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for B1IS70

Entry ID Method Resolution Chain Position Source
4B5S X-ray 168 A A/B 1-251 PDB
4B5T X-ray 192 A A/B 1-251 PDB
4B5U X-ray 191 A A/B 1-251 PDB
4B5V X-ray 204 A A/B 1-251 PDB
4B5W X-ray 179 A A/B/C/D/E/F 1-256 PDB
4B5X X-ray 180 A A/B 1-262 PDB
AF-B1IS70-F1 Predicted AlphaFoldDB

No variants for B1IS70

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1IS70

No associated diseases with B1IS70

1 regional properties for B1IS70

Type Name Position InterPro Accession
domain HpcH/HpaI aldolase/citrate lyase domain 15 - 241 IPR005000

Functions

Description
EC Number 4.1.2.52 Aldehyde-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde.
4-hydroxy-2-ketopimelate aldolase activity Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
phenylacetate catabolic process The chemical reactions and pathways resulting in the breakdown of phenylacetate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MENSFKAALK AGRPQIGLWL GLSSSYSAEL LAGAGFDWLL IDGEHAPNNV QTVLTQLQAI
70 80 90 100 110 120
APYPSQPVVR PSWNDPVQIK QLLDVGTQTL LVPMVQNADE AREAVRATRY PPAGIRGVGS
130 140 150 160 170 180
ALARASRWNR IPDYLQKAND QMCVLVQIET REAMKNLPQI LDVEGVDGVF IGPADLSADM
190 200 210 220 230 240
GYAGNPQHPE VQAAIEQAIV QIRESGKAPG ILIANEQLAK RYLELGALFV AVGVDTTLLA
250 260
RAAEALAARF GAQATAVKPG VY