B1IRC9
Gene name |
kefC |
Protein name |
Glutathione-regulated potassium-efflux system protein KefC |
Names |
K(+)/H(+) antiporter |
Species |
Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) |
KEGG Pathway |
ecl:EcolC_3608 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B1IRC9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B1IRC9-F1 | Predicted | AlphaFoldDB |
No variants for B1IRC9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B1IRC9 | |||||
No associated diseases with B1IRC9
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| glutathione-regulated potassium exporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state. |
| solute:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). |
| toxic substance binding | Binding to a toxic substance, a poisonous substance that causes damage to biological systems. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| response to methylglyoxal | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSHTLIQAL | IYLGSAALIV | PIAVRLGLGS | VLGYLIAGCI | IGPWGLRLVT | DAESILHFAE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IGVVLMLFII | GLELDPQRLW | KLRAAVFGCG | ALQMVICGGL | LGLFCMLLGL | RWQVAELIGM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TLALSSTAIA | MQAMNERNLM | VTQMGRSAFA | VLLFQDIAAI | PLVAMIPLLA | TSSASTTMGA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FALSALKVAG | ALVLVVLLGR | YVTRPALRFV | ARSGLREVFS | AVALFLVFGF | GLLLEEVGLS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MAMGAFLAGV | LLASSEYRHA | LESDIEPFKG | LLLGLFFIGV | GMSIDFGTLL | ENPLRIVILL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGFLIIKIAM | LWLIARPLQV | PNKQRRWFAV | LLGQGSEFAF | VVFGAAQMAN | VLEPEWAKSL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLAVALSMAA | TPILLVILNR | LEQSSTEEAR | EADEIDEEQP | RVIIAGFGRF | GQITGRLLLS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SGVKMVVLDH | DPDHIETLRK | FGMKVFYGDA | TRMDLLESAG | AAKAEVLINA | IDDPQTNLQL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TEMVKEHFPH | LQIIARARDV | DHYIRLRQAG | VEKPERETFE | GALKTGRLAL | ESLGLGPYEA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RERADVFRRF | NIQMVEEMAM | VENDTKARAA | VYKRTSAMLS | EIITEDREHL | SLIQRHGWQG |
| 610 | |||||
| TEEGKHTGNM | ADEPETKPSS |