B1I370

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Desulforudis audaxviator (strain MP104C)
KEGG Pathway
dau:Daud_0912
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

180-250 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1I370

Entry ID Method Resolution Chain Position Source
AF-B1I370-F1 Predicted AlphaFoldDB

No variants for B1I370

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1I370

No associated diseases with B1I370

4 regional properties for B1I370

Type Name Position InterPro Accession
domain DHHA1 domain 731 - 871 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 652 - 695 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 553 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 708 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNSSEIRKRY LEFFAARGHR VIPSASLIPG NDPTLLWTSA GMVPFKPYFT GVATPEFRRV
70 80 90 100 110 120
VTCQKCLRTP DIEMVGRTAR HHTFFEMLGN FSFGDYFKER AIPWAWEFVT RDLGLAPEHL
130 140 150 160 170 180
WISVYLDDNE AFDHWRGLGV PAERIVRLGR DTNFWEIGVG PCGPCSEVYY DRGPAYGCES
190 200 210 220 230 240
ASCGPGCDCD RWLEIWNLVF IQYFRNEAGD YSPLESPGID TGMGLERVAS VLQGVNTNFD
250 260 270 280 290 300
TDLFRGLIDY TAGVLGVRYG DDPAGDAALK VIADHGRAIT FAIADGVLPS NEGRGYVIRR
310 320 330 340 350 360
LLRRAVRKAL LLGREKPFLE GVALAVIEQM AGAYPELETA RDSVRKVVRF EEERFRQTLT
370 380 390 400 410 420
QGNEIIGRLI AEARAEKRST LEGAAAFQLY DTYGFPLELT REICAEQGLA VDEAGFEAAL
430 440 450 460 470 480
KAQQQKARSS RRETRYVEER ETFFRNLRDE IGLTRFVGYE QLEADAGVRA LIRDGQRVPA
490 500 510 520 530 540
AGSGEQVSLV VDTTPCYAES GGQVGDHGLI EGENVRGRIT DTFAPVEGLH VHEVVVEAGV
550 560 570 580 590 600
LEEGARIRIL VDGSRRRKIC RNHTATHLLH RTLKAVLGTH VNQAGSLVAP ERLRFDFTHI
610 620 630 640 650 660
QPLSEAELAE VESRINEIVL SNLRVESFQT SFDRARELGA VALFGEKYGD LVRVVQIDGV
670 680 690 700 710 720
SMELCGGTHV LSTAEIGPVK ITAESSVGAG LRRLEAVTGM EALAFLNSRN EQLHRIAQAV
730 740 750 760 770 780
RVPVSELVVH VERLLDHQKK LQRENEQLQD RLQVYEVKEL LDRASTHEGV RILATSVRAR
790 800 810 820 830 840
DMAELRSMLD LLRERLGSAV IVLGSAVNGK VSLVASVSRD LVARGLHAGA IIKEAAAVAG
850 860 870
GGGGGRPEMA QAGGKNPEKL TEALEKARQV VLRRVDGGSA