B1HXY7

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Lysinibacillus sphaericus (strain C3-41)
KEGG Pathway
lsp:Bsph_4241
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1HXY7

Entry ID Method Resolution Chain Position Source
AF-B1HXY7-F1 Predicted AlphaFoldDB

No variants for B1HXY7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1HXY7

No associated diseases with B1HXY7

5 regional properties for B1HXY7

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 52 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 412 - 604 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 651 - 766 IPR013155
domain Methionyl/Leucyl tRNA synthetase 39 - 170 IPR015413
domain Leucyl-tRNA synthetase, editing domain 219 - 398 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSFNHQQIEK KWQQYWADNK TFKTENETEK PKFFALDMFP YPSGAGLHVG HPEGYTATDI
70 80 90 100 110 120
LSRFKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT AKNIATFKRQ IQELGFSYDW
130 140 150 160 170 180
DREINTTDPA YYKWTQWIFI QLYKKGLAYV DEVAVNWCPA LGTVLANEEV IDGKSERGGH
190 200 210 220 230 240
PVERRPMKQW MLKITAYADR LIDDLEEVDW PESIKDMQRN WIGRSEGAEV TFGIDGTDEN
250 260 270 280 290 300
FTVFTTRPDT LFGATYCVLA PEHKLVEQIT TVEQRQAVED YLEKVKMKSD LERTDLAKEK
310 320 330 340 350 360
TGVFTGAYAV NPINGKKVPI WIADYVLVSY GTGAIMAVPA HDERDYEFAS AFSLDIVPVL
370 380 390 400 410 420
EGGDISKEAF TGDGQHINSD FLNGLNKVEG IAKAIEWLEE KGVGEKKISY RLRDWLFSRQ
430 440 450 460 470 480
RYWGEPIPMI HWEDGTITPV PEEELPLMLP KTDNIRPSGT GESPLANIAE WVNVVDPATG
490 500 510 520 530 540
KKGRRETNTM PQWAGSSWYF LRYIDPTNTE AIADPELLKR WLPVDIYIGG AEHAVLHLLY
550 560 570 580 590 600
ARFWHKVLYD LGVVHTKEPF QKLFNQGMIL GEGNEKMSKS KGNVVNPDEI IESHGSDTLR
610 620 630 640 650 660
LYEMFMGPLE ASVAWSTNGL DGARRFLDRI WRLLVNEEDG TISAKIQVSD DKTLEKSYHQ
670 680 690 700 710 720
TVKKVTEDYE GIRFNTAISQ MMVFINDCYK AEVIPTAYAE GFVKMLAPIA PHIAEELWNL
730 740 750 760 770 780
LGHEGTLSYE QWPTYDESKL VDDEVEVAVQ VAGKVRAKIV VAKDASKEDI EKVALADEKV
790 800
QEYMAGKDLV KVIVIPGKLV NIVVK