B1HMZ6

PR
Gene name
rpoB
Protein name
DNA-directed RNA polymerase subunit beta
Names
RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta
Species
Lysinibacillus sphaericus (strain C3-41)
KEGG Pathway
lsp:Bsph_4630
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1131-1191 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1HMZ6

Entry ID Method Resolution Chain Position Source
AF-B1HMZ6-F1 Predicted AlphaFoldDB

No variants for B1HMZ6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1HMZ6

No associated diseases with B1HMZ6

8 regional properties for B1HMZ6

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 680 - 1074 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 927 - 939 IPR007121
domain RNA polymerase Rpb2, domain 7 1076 - 1150 IPR007641
domain RNA polymerase Rpb2, domain 2 143 - 292 IPR007642-1
domain RNA polymerase Rpb2, domain 2 375 - 415 IPR007642-2
domain RNA polymerase, beta subunit, protrusion 31 - 459 IPR007644
domain RNA polymerase Rpb2, domain 3 474 - 542 IPR007645
domain DNA-directed RNA polymerase, beta subunit, external 1 domain 552 - 619 IPR019462

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNELTGQLVQ YGQHRQRRSF ARIKEVLELP NLIEIQTASY EWFLEEGLRE MFRDISPIED
70 80 90 100 110 120
FTGNLSLEFI DYSLGDPKYD VDECKERDVT YAAPLRVKVR LYNKETDEVK EQDVFMGDFP
130 140 150 160 170 180
LMTETGTFII NGAERVIVSQ LVRSPSVYFH DKTDKNGKKG FGATVIPNRG AWLEYETDAK
190 200 210 220 230 240
DVVYVRIDRT RKLPVTVLLR ALGFGSDQEI IDIIGDNEYL RNTLEKDNSE STEKALLEIY
250 260 270 280 290 300
ERLRPGEPPT VESAKSLLYS RFFDAKRYDL ANVGRYKMNK KLHIKNRLFN QTIAETLVDP
310 320 330 340 350 360
ETGEILVEKG TVLDRRTLDK ILPYLEDSSK GIGFRTLSQV GGVLEDDVTI QSIKIYAPKD
370 380 390 400 410 420
EAQKEINIIS NAYIDEEVKN ITPADVLSSV SYFFNLLYQV GATDDIDHLG NRRLRSVGEL
430 440 450 460 470 480
LQNQFRIGLS RMERVVRERM SINDTAAIVP QQLINIRPVI ASIKEFFGSS QLSQFMDQTN
490 500 510 520 530 540
PLAELTHKRR LSALGPGGLT RERAGFEVRD VHYSHYGRMC PIETPEGPNI GLINSLSSFA
550 560 570 580 590 600
KVNKFGFIET PYRRIDHETG QVTDQIDYLT ADEEDNYYVA QANSPLNPDG SFANDEVVGR
610 620 630 640 650 660
FRGDNTVFNK AQMDYMDVSP KQVVSAATAC IPFLENDDSN RALMGANMQR QAVPLLNPEA
670 680 690 700 710 720
PFVGTGMEHV DARDSGAAVV AKYDGIVEHV EARSIHVRRI EVVDGKEVKG DLTKYKLQKF
730 740 750 760 770 780
IRSNQGTSYN QRPLVKVGER VKPRDILADG PSMEKGELAL GRNVLVAFMT WNGFNYEDAV
790 800 810 820 830 840
IMSERLVKDD VYTSVHIEEY ESESRDTKLG PEEITRDIPN VGEDALRNLD ERGIIRIGAE
850 860 870 880 890 900
VRDGDILVGK VTPKGVTELT AEERLLHAIF GEKAREVRDT SLRVPHGAGG IILDVKVFNR
910 920 930 940 950 960
EDGDELPPGV NQLVRAYIVQ KRKIRVGDKM AGRHGNKGVI SRILPEEDMP FMPDGTPVDI
970 980 990 1000 1010 1020
MLNPLGVPSR MNIGQVLELH LGMASRYLGV HMATPVFDGA NEEDVWETME EAGMNRDGKT
1030 1040 1050 1060 1070 1080
ILYDGRSGEP FDNRVSVGIM YMIKLAHMVD DKLHARSTGP YSLVTQQPLG GKAQFGGQRF
1090 1100 1110 1120 1130 1140
GEMEVWALEA YGAAYTLQEI LTVKSDDVVG RVKTYEAIVK GESVPEPGVP ESFKVLIKEL
1150 1160 1170 1180 1190
QSLGMDVKML TVNDEEVELR DLDEEEDLQP ADALNIAPQP DTEEEPVESF E