B1H072

PR
Gene name
ligA
Protein name
DNA ligase
Names
Polydeoxyribonucleotide synthase [NAD(+)]
Species
Endomicrobium trichonymphae
KEGG Pathway
rsd:TGRD_421
EC number
6.5.1.2: Forming phosphoric ester bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-240 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1H072

Entry ID Method Resolution Chain Position Source
AF-B1H072-F1 Predicted AlphaFoldDB

No variants for B1H072

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1H072

No associated diseases with B1H072

7 regional properties for B1H072

Type Name Position InterPro Accession
domain BRCT domain 587 - 666 IPR001357
domain Zinc-finger, NAD-dependent DNA ligase C4-type 404 - 431 IPR004149
domain NAD-dependent DNA ligase, OB-fold 321 - 395 IPR004150
domain NAD-dependent DNA ligase, adenylation 6 - 318 IPR013839
domain NAD-dependent DNA ligase, N-terminal 5 - 445 IPR013840
active_site NAD-dependent DNA ligase, active site 116 - 145 IPR018239
domain DisA/LigA, helix-hairpin-helix motif 507 - 570 IPR041663

Functions

Description
EC Number 6.5.1.2 Forming phosphoric ester bonds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
DNA ligase (NAD+) activity Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIMGNIQNRI DYLRKELIRH NGLYYESNNP EISDSEYDNL AKELEQIEKE NPLFALPDSP
70 80 90 100 110 120
TKKISGFVSS SFEQIKHSSP MLSLDNTYSQ KETAKWYERI EKNLNNKNTE FTIEPKIDGV
130 140 150 160 170 180
SASLTYINGS LTAGATRGDG ETGEDITENI KKVKNIPYKL KADNPPYFFE LRGEVYIDKS
190 200 210 220 230 240
DFRKLNEEIL MSVGQKFANS RNAASGSLRQ KNPQITAERK LRFFVHSLGK IDGKQFESQS
250 260 270 280 290 300
DFLQYCRKCG FQLQDNFKIC HSLKEIMDFM EIMINNRDLL HYEIDGLVIK VNSLQLQKEL
310 320 330 340 350 360
GYTNKSPRWA IAFKFPAKQA TTKLSRIRVQ VGRTGIITPS AILESVTLAG VTISHATLHN
370 380 390 400 410 420
FEEIERLNVN EGDTVLIERA GDVIPKIVKV VKKENRGFFK PPHNCPSCNS GIVKENEEEV
430 440 450 460 470 480
AYRCINPECP AQFRRHLIHF VSRNAMDIDG FGKAVIDQFL DRKKIQVLAD IYYLKYDDFI
490 500 510 520 530 540
KLDLFKEKKT SNLMKAVAAS KKHPLSKLLF ALGIRRIGEK VSEIIAKKFK SMEALFNASI
550 560 570 580 590 600
EDFTRVPEIG SILALSLKEF FENKTVRNVI DNLIAAGVNM IEPEAEQSGT QFDGKMFVLT
610 620 630 640 650 660
GELKNHTREQ AGKIIRSLGG KVASSVSKKT DYIVAGVNAG SKLKKAKELN VKIVDEAEFD
670
ILTGKLSLIE NTKF