B0XQ72

PR
Gene name
hulA (AFUB_008950)
Protein name
Probable E3 ubiquitin-protein ligase hulA
Names
HECT ubiquitin ligase A, HECT-type E3 ubiquitin transferase hulA
Species
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
KEGG Pathway
EC number
2.3.2.26: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

110-352 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0XQ72

Entry ID Method Resolution Chain Position Source
AF-B0XQ72-F1 Predicted AlphaFoldDB

No variants for B0XQ72

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0XQ72

No associated diseases with B0XQ72

1 regional properties for B0XQ72

Type Name Position InterPro Accession
domain GPCR, rhodopsin-like, 7TM 50 - 394 IPR017452

Functions

Description
EC Number 2.3.2.26 Aminoacyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

2 GO annotations of biological process

Name Definition
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGSNLPAQPN LRLTTDGLYK RDVFRFPDPF AVATVGGEQT HTTSVIKKTL NPYWNEMFDL
70 80 90 100 110 120
RVNEDSILAI QIFDQKKFKK KDQGFLGVIN VRIGDVIDLQ MGGDEMLTRD LKKSNDNLVV
130 140 150 160 170 180
HGKLIINLST NLSTPNTNQA NGLHRSHVQS STSSGLVPQV APSSSHPAAS GTAPVDPSAS
190 200 210 220 230 240
NPSLNPQRVP STTRPSSTAA PASAAGAAVS NSHGSRTNLS SFEDSQGRLP AGWERREDNL
250 260 270 280 290 300
GRTYYVDHNT RTTTWTRPSS NYNEHAQRSQ REANMQLERR AHQSRMLPED RTGANSPNLP
310 320 330 340 350 360
ESSQQAHTPP AGGSANAVSM MATGATTAGT GELPPGWEQR TTPEGRPYFV DHNTRTTTWV
370 380 390 400 410 420
DPRRQQYIRM YGQNANGTNT TIQQQPVSQL GPLPSGWEMR LTNTARVYFV DHNTKTTTWD
430 440 450 460 470 480
DPRLPSSLDQ GVPQYKRDFR RKLIYFRSQP ALRIMSGQCH VKVRRNNIFE DSYAEIMRQS
490 500 510 520 530 540
ASDLKKRLMI KFDGEDGLDY GGLSREFFFL LSHEMFNPFY CLFEYSAHDN YTLQINPHSG
550 560 570 580 590 600
VNPEHLNYFK FIGRVVGLAI FHRRFLDSFF IGAFYKMMLR KKVSLQDMEG VDEDLHRNLT
610 620 630 640 650 660
WTLDNDIEGV LELTFSVDDE KFGERRTIDL KPGGRDIPVT NENKAEYVEL VTEWKIVKRV
670 680 690 700 710 720
EEQFNAFMSG FNELIPADLV NVFDERELEL LIGGIADIDV DDWKKHTDYR GYQESDEVIQ
730 740 750 760 770 780
NFWKIVRSWD AEQKSRLLQF TTGTSRIPVN GFKDLQGSDG PRRFTIEKSG DPAALPKSHT
790 800 810
CFNRLDLPPY KSYETLEHKM SIAVEETLGF GQE