B0VXE8
Gene name |
CDK14 (PFTK1) |
Protein name |
Cyclin-dependent kinase 14 |
Names |
Cell division protein kinase 14 |
Species |
Callithrix jacchus (White-tufted-ear marmoset) |
KEGG Pathway |
cjc:100391008 |
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
227-250 (Activation loop from InterPro)
Target domain |
89-373 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for B0VXE8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B0VXE8-F1 | Predicted | AlphaFoldDB |
No variants for B0VXE8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B0VXE8 | |||||
No associated diseases with B0VXE8
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic cyclin-dependent protein kinase holoenzyme complex | Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| G2/M transition of mitotic cell cycle | The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of canonical Wnt signaling pathway | Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTRNCQGMD | SVIKPLDTIP | EDKKVRVQRT | QSTFDPFEKP | TNQVKRVHSE | NNACINFKTS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| STGKESPKVR | RHSSPSSPTS | PKFGKADSYE | KLEKLGEGSY | ATVYKGKSKV | NGKLVALKVI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RLQEEEGTPF | TAIREASLLK | GLKHANIVLL | HDIIHTKETL | TLVFEYVHTD | LCQYMDKHPG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GLHPDNVKLF | LFQLLRGLSY | IHQRYILHRD | LKPQNLLISD | TGELKLADFG | LARAKSVPSH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TYSNEVVTLW | YRPPDVLLGS | TEYSTCLDMW | GVGCIFVEMI | QGVAAFPGMK | DIQDQLERIF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LVLGTPNEDT | WPGVHSLPHF | KPERFTLYSS | KNLRQAWNKL | SYVNHAEDLA | SKLLQCSPKN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RLSAQAALSH | EYFSDLPPRL | WELTDMSSIF | TVPNVRLQPE | AGESMRAFGK | NNSYGKSLSN |
| SKH |