B0UV12

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Histophilus somni (strain 2336) (Haemophilus somnus)
KEGG Pathway
hsm:HSM_0054
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

792-862 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0UV12

Entry ID Method Resolution Chain Position Source
AF-B0UV12-F1 Predicted AlphaFoldDB

No variants for B0UV12

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0UV12

No associated diseases with B0UV12

1 regional properties for B0UV12

Type Name Position InterPro Accession
domain Membrane fusion protein, biotin-lipoyl like domain 89 - 137 IPR039562

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDYKNTLNL PETGFPMRGD LAKREPDMLK NWYDKNLYQK VREASKGKKT FILHDGPPYA
70 80 90 100 110 120
NGTLHLGHAV NKILKDIIMK SKTALGFDTP YVPGWDCHGL PIELKVEGLV GKPNEKISAA
130 140 150 160 170 180
EFRQACRDYA KEQVEGQKAD FIRMGVLGDW DNPYLTMNFE TEAEIIRTLG KVIQNGHLYK
190 200 210 220 230 240
GSKPVHWCLD CASSLAEAEV EYEDKVSPSI YVRFAAVSAA EVEEKFNALG KGQGALSAVI
250 260 270 280 290 300
WTTTPWTLPS NRAIAVNAEL EYQLVQLGDE RVILAAELVQ AVQNALKIEQ LEILGSTTGQ
310 320 330 340 350 360
DLELVRFHHP FYDFSVPIIL GDHVTVDGGT GLVHTAPDHG QDDFVVSKKY GLEMAGLVAN
370 380 390 400 410 420
DGKFISSTPF FAGKGVFEAN DLVLEKLKET GALLKLERIK HSYPHCWRHK TPIIFRATPQ
430 440 450 460 470 480
WFIGMETQDL RIKALSEIKS VRWIPSWGEA RIDKMVANRP DWCISRQRTW GVPMTMFVHN
490 500 510 520 530 540
ETEELHPRTL ELLEDIAKRV EKAGIQAWWD LDPAELLGED AKTYHKVPDT LDVWFDSGST
550 560 570 580 590 600
YASVVEQRPE FNGKSTDMYL EGSDQHRGWF MSSLMLSTAT NNKAPYKQVL THGFTVDEKG
610 620 630 640 650 660
RKMSKSLGNV IVPSEVWNKN GADILRLWVA STDYTGEIAV SHKILNSAGD TYRRIRNTAR
670 680 690 700 710 720
FLLANLNGFD PKNDLVNPEE MISLDRWAVS CALEAQNEIK EAYDNYQFHT VVQRLMRFCS
730 740 750 760 770 780
IEMGSFYLDI IKDRQYTTKA DSLARRSCQT ALWHISEALV RWIAPILSFT ADEIWGYLPK
790 800 810 820 830 840
LDNRAEFVFT EEFYDGLFGL DESDKLDDTY WQQLLKVRAE VNRVLEQARN DKLIGAGLEA
850 860 870 880 890 900
KVTVYASEEI RPLLEQLGNE LRFVLITSQV VVKPLSKADV AESELTGLAI KVERADGEKC
910 920 930
PRCWHFSTDI GSNKEHSHIC GRCIENVEGN GEQRQFA