B0UGC4

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Methylobacterium sp (strain 4-46)
KEGG Pathway
met:M446_5834
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

381-467 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0UGC4

Entry ID Method Resolution Chain Position Source
AF-B0UGC4-F1 Predicted AlphaFoldDB

No variants for B0UGC4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0UGC4

No associated diseases with B0UGC4

4 regional properties for B0UGC4

Type Name Position InterPro Accession
domain DHHA1 domain 742 - 883 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 653 - 706 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 6 - 555 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 2 - 719 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGVNEIRST FLDYFAKHGH EVVPSSPLVP RNDPTLMFTN AGMVQFKNVF TGVEKRPYHR
70 80 90 100 110 120
AATAQKCVRA GGKHNDLDNV GYTARHHTFF EMLGNFSFGD YFKPLAIELA WNLVTKEFGL
130 140 150 160 170 180
DRSKLLVTVY ADDDDAATLW RKIAGFPEER IIRIGTSDNF WQMGDTGPCG PCSEIFIDQG
190 200 210 220 230 240
PELWGGPPGS PEEDGDRFLE FWNLVFMQYE QIEPGNRVGL PRPSIDTGMG LERMAAILQG
250 260 270 280 290 300
VKSNYDTDLF RSLIDAVAHQ VGRPPEGAQT ASYRVIADHL RAASFLVADG VLPGNEGRGY
310 320 330 340 350 360
VLRRIMRRAM RHAQLLGARD PMMYRLVPTL VREMGQAYPE LVRAESLISE TLRLEETRFR
370 380 390 400 410 420
RTLERGLSIL DAETRDLSEG QNLSGETAFT LYDTYGFPLD LTQDALKSRG IGVDTDAFKA
430 440 450 460 470 480
AMERQRAAAR AAWAGSGEAA TETLWYALRE RVGATEFLGY EAETAEGVVT ALVRGGVEVE
490 500 510 520 530 540
ALASGEEGLL VVSQTPFYGE SGGQVGDTGT VAAAGLRARV TDTEKKLGDL FVHHVAVEEG
550 560 570 580 590 600
RLTVGQAVEL RVDHARRAAI RAHHSATHLL HEALRQVLGD HVAQKGSLVS PERLRFDFSH
610 620 630 640 650 660
PKPMNDDEVA AVEEMANRVL LQNGPVVTKL MAVDDAIATG ARALFGEKYG DEVRVVSMGE
670 680 690 700 710 720
DQGGDGRRRT FSVELCGGTH VGRTGEIGLI TVVGEGAVAS GVRRIEAMTG DAARRHLAEE
730 740 750 760 770 780
SRRLAAVAGL LKVPPAEAAD RLAALIEDRR RLERELSEAR RKLAMGGGGA GEEPVREVAG
790 800 810 820 830 840
VKLMARSVEG VEMRDLKSLA DEGKKRLGSG VVAIVGVAPD GKAGLVVGVT DDLTDRFDAV
850 860 870 880
ALVRAGSERL GGKGGGGRRD MAQAGGPDGA AAQDALAAIE AALAAA