B0TZT2
Gene name |
mdh |
Protein name |
Malate dehydrogenase |
Names |
|
Species |
Francisella philomiragia subsp. philomiragia (strain ATCC 25017 / FSC 153 / O#319-036) |
KEGG Pathway |
fph:Fphi_1620 |
EC number |
1.1.1.37: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B0TZT2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B0TZT2-F1 | Predicted | AlphaFoldDB |
No variants for B0TZT2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B0TZT2 | |||||
No associated diseases with B0TZT2
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.1.37 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| L-malate dehydrogenase activity | Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| carboxylic acid metabolic process | The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). |
| tricarboxylic acid cycle | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARKKIALIG | AGNIGGTLAH | LSLIKQLGDV | VLFDIAPGMP | QGKALDLLQS | CPIEGVDFKV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RGTNDYKDLE | HSDVVIVTAG | VPRKPGMSRD | DLLGINIKVM | QAVGEGIKHN | CPDAFVICIT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NPLDIMVNML | QKFSGVPDNK | IVGMAGVLDS | ARFRTFLADE | LNVSVQQVQA | YVMGGHGDTM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VPLTKMSNVA | GVSLEQLVKE | GKISQERLDS | IVARTRNGGG | EIVALLKTGS | AYYAPAAAGI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QMAESYLRDK | KMILPCAAKI | KAGMYGVDED | LFVGVPTEIS | ANGVRPIHVE | ISEKEKEQLQ |
| 310 | |||||
| VSINAVKELN | KAAAEILAN |