B0TWF7

PR
Gene name
dnaA
Protein name
Chromosomal replication initiator protein DnaA
Names
Species
Francisella philomiragia subsp. philomiragia (strain ATCC 25017 / FSC 153 / O#319-036)
KEGG Pathway
fph:Fphi_0842
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

70-163 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0TWF7

Entry ID Method Resolution Chain Position Source
AF-B0TWF7-F1 Predicted AlphaFoldDB

No variants for B0TWF7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0TWF7

No associated diseases with B0TWF7

4 regional properties for B0TWF7

Type Name Position InterPro Accession
domain AAA+ ATPase domain 132 - 276 IPR003593
domain Chromosomal replication initiator, DnaA C-terminal 349 - 438 IPR013159
domain Chromosomal replication initiator protein DnaA 101 - 319 IPR013317
domain DnaA N-terminal domain 5 - 63 IPR024633

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA replication origin binding Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.

2 GO annotations of biological process

Name Definition
DNA replication initiation The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
regulation of DNA replication Any process that modulates the frequency, rate or extent of DNA replication.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTWNKCLKK LKKSLSTFEY KTWIKPIHVE QNNYLFTIYC NNEYFKKHIK SKYGEIISST
70 80 90 100 110 120
IQEFHDGDLL IEYSNKKFSG EKSPEVTSVG PQANFFNQKN VEIKDDSEET SLNQEPKKSQ
130 140 150 160 170 180
KKLSSKNSAS QELFGFDEAM LITDKDDQEY SFGLPLKEKY VFDSFVVGDA NKIARAAAMQ
190 200 210 220 230 240
VSINPGKLHN PLFIYGGSGL GKTHLMQAIG NHAREVNPNA RIIYTNSEQF IKDYVNSIRL
250 260 270 280 290 300
QDQDEFQRVY RSADILLIDD IQFIAGKEGT AQEFFHTFNA LYENGKQIIL TSDKYPNEIE
310 320 330 340 350 360
GLEERLVSRF GYGLTVSVDM PDLETRIAIL LKKAHDLGQK LPNETAAFIA ENVRTNVREL
370 380 390 400 410 420
EGALNRVLTT SKFNHKDPTI EVAQACLRDV IKIQEKKVKI DNIQKVVADF YRIRVKDLTS
430 440 450 460 470 480
NQRSRNIARP RQIAMSLARE LTSHSLPEIG NAFGGRDHTT VMHAVKAITK LRQSNTSISD
490
DYELLLDKIS R