B0TK13

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Shewanella halifaxensis (strain HAW-EB4)
KEGG Pathway
shl:Shal_1231
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

768-858 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0TK13

Entry ID Method Resolution Chain Position Source
AF-B0TK13-F1 Predicted AlphaFoldDB

No variants for B0TK13

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0TK13

No associated diseases with B0TK13

5 regional properties for B0TK13

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 611 - 801 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 13 - 124 IPR007695
domain DNA mismatch repair protein MutS, core 274 - 595 IPR007696
domain DNA mismatch repair protein MutS, connector domain 133 - 257 IPR007860
domain DNA mismatch repair protein MutS, clamp 432 - 521 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTAIDPQGLE KHTPMMRQYL TLKAQHPDML LFYRMGDFYE LFYEDAKRAS ELLGISLTAR
70 80 90 100 110 120
GKSGGDPIPM AGLPYHAVEG YLAKLVQLRV SVAICEQIGD PATSKGPVER KVVRIVTPGT
130 140 150 160 170 180
LTDEALLQER QDNLLAALYQ GKTGYGYATL DVASGRFVIT ELANTEALEA ELQRTNPAEL
190 200 210 220 230 240
LYSEDFSEMS LIAAINGTRR RPEWEFDYDT CHRLLLNQFG TKDLKGFGIE DARLSLQAAG
250 260 270 280 290 300
CLMQYVKDTQ RTALPHINSI VRFNQSDSIV LDAATRRNLE LTVNLQGGRE NTLASVLDNT
310 320 330 340 350 360
VTPMGSRMLQ RWLHQPLRDH DIIRARQVSI EELLGNANYE ILSEDLKAIG DIERITTRIA
370 380 390 400 410 420
LRNARPRDFA RLRQALALLP QLQQTLTQAA APHLKYLSQV IGEFPDELEL LSRAVVDNPP
430 440 450 460 470 480
MLIRDGGVIR EGYNEELDQW RKLSEGATDY LHELEAREKQ QTGISTLKVG YNRVHGYYIE
490 500 510 520 530 540
VSRRESDLVP LSYQRRQTLK NTERYIIPEL KEHEEKVLSS QGRALALEKQ LWEQLFDLIL
550 560 570 580 590 600
PKLHELQDFA RASAELDVLC NFAERAESLN YHCPDLSTAP GIQIEAGRHP VVEQVSQSPF
610 620 630 640 650 660
IANPVTLNNE RKMLIVTGPN MGGKSTYMRQ VALITLMAHI GCYVPAEHAV IGPVDRIFTR
670 680 690 700 710 720
IGASDDLASG RSTFMVEMTE TANILHNATP NSLVLMDEIG RGTSTYDGLS LAWSAAEYLA
730 740 750 760 770 780
KHLQAMTLFA THYFELTQLP ELLSNVENVH LDAVEHGDSI VFMHAVQEGA ASRSYGLQVA
790 800 810 820 830 840
ALAGVPNCVI SAAKHKLHQL ESRDHGKESC DAQQPLQQSI SFSAPTPSPA LEALAKLNPD
850
ELTPRQALDY LYNLKKLAL