B0TDZ7

PR
Gene name
pyrF
Protein name
Orotidine 5'-phosphate decarboxylase
Names
OMP decarboxylase, OMPDCase, OMPdecase
Species
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
KEGG Pathway
hmo:HM1_0241
EC number
4.1.1.23: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

72-147 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0TDZ7

Entry ID Method Resolution Chain Position Source
AF-B0TDZ7-F1 Predicted AlphaFoldDB

No variants for B0TDZ7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0TDZ7

No associated diseases with B0TDZ7

2 regional properties for B0TDZ7

Type Name Position InterPro Accession
domain CRAL-TRIO lipid binding domain 117 - 282 IPR001251
domain CRAL/TRIO, N-terminal domain 67 - 102 IPR011074

Functions

Description
EC Number 4.1.1.23 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
orotidine-5'-phosphate decarboxylase activity Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP.

2 GO annotations of biological process

Name Definition
'de novo' pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
'de novo' UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEAKDRLIVA LDVDTRDEAI SIVNAVGEHC GLFKVGMQLH NSAGFAVTEE ILSMGFPVFL
70 80 90 100 110 120
DLKFHDIPNT VGKAATVVSR RGVKMFTVHA AGGREMLRQA VKGAREGQGE RRSGGPLVLA
130 140 150 160 170 180
ITVLTSVSQA VLHDEVGLPG SVEENVVRFA RLAQAAGVQG VVASPQEIRP IRAACGDDFV
190 200 210 220 230 240
IVTPGVRPLW AGTDDQARIM TPAKAMEAGA TYLVVGRPIT AAPSRAEAAK RIVEEMAEGL
ARR