B0T019

PR
Gene name
argS
Protein name
Arginine--tRNA ligase
Names
Arginyl-tRNA synthetase, ArgRS
Species
Caulobacter sp (strain K31)
KEGG Pathway
cak:Caul_4389
EC number
6.1.1.19: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0T019

Entry ID Method Resolution Chain Position Source
AF-B0T019-F1 Predicted AlphaFoldDB

No variants for B0T019

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0T019

No associated diseases with B0T019

3 regional properties for B0T019

Type Name Position InterPro Accession
conserved_site Fumarate lyase, conserved site 276 - 285 IPR020557
domain Fumarate lyase, N-terminal 8 - 301 IPR022761
domain Argininosuccinate lyase, C-terminal 365 - 432 IPR029419

Functions

Description
EC Number 6.1.1.19 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
arginine-tRNA ligase activity Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

1 GO annotations of biological process

Name Definition
arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDLKRSLSE AAAAAFQAAG LSPDFGRVTA SDRPDLADFQ CNGALAAAKS AKRNPREIAV
70 80 90 100 110 120
QVVDVLKADP RLASVEIAGV GFINMRVSTD ALSIRANEIA ADPRAGAEPL AHPRRVLVDY
130 140 150 160 170 180
AGPNVAKPMH VGHLRASIIG ESVKRLYRFR GDDVVGDAHF GDWGFQMGLL ISAIMEEDAF
190 200 210 220 230 240
IRALLERLVE APREFSKADE DKVMSEFAQR VTLDDLDRLY PAASARQKED PEFKEKARKA
250 260 270 280 290 300
TAELQNGRFG YRLLWRHFVN ISRVALEREF HALGVDFDLW KGESDVQDLI APMVRQLEVK
310 320 330 340 350 360
GLLVDDQGAR IVRVARPGET KKKKLPDGSV VEVESPDPLL VVSSEGSAMY GTTDLATILD
370 380 390 400 410 420
RRKSFDPHLI LYCVDQRQAD HFEQVFRAAY LAGYAEPGSL EHIGFGTMNG SDGKPFKTRA
430 440 450 460 470 480
GGVLKLHDLI EMAREKARER LREAGLGAEL SQEAFEETAH KVGIAALKFA DLQNFRGTSY
490 500 510 520 530 540
VFDLDRFTSF EGKTGPYLLY QSVRIKSILR KAAEQKVVSG AIIVGEPAER DLTLLLDAFE
550 560 570 580 590 600
GALSEAYDKK APNFIAEHAY KLAQTFSKFY AACPILSADN DATRASRLAL AETTLKQLEL
610
ALDLLGIEAP ERM