B0SSI3

PR
Gene name
rpoC
Protein name
DNA-directed RNA polymerase subunit beta'
Names
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'
Species
Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
KEGG Pathway
lbi:LEPBI_I1971
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1354-1433 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0SSI3

Entry ID Method Resolution Chain Position Source
AF-B0SSI3-F1 Predicted AlphaFoldDB

No variants for B0SSI3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0SSI3

No associated diseases with B0SSI3

6 regional properties for B0SSI3

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 333 - 474 IPR000722
domain RNA polymerase, N-terminal 224 - 503 IPR006592
domain RNA polymerase Rpb1, domain 3 478 - 618 IPR007066
domain RNA polymerase Rpb1, domain 1 5 - 331 IPR007080
domain RNA polymerase Rpb1, domain 5 729 - 1312 IPR007081
domain RNA polymerase Rpb1, domain 4 647 - 717 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
magnesium ion binding Binding to a magnesium (Mg) ion.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRNYNSFESI TIRLASPERI KEWSFGEVKK PETINYRTLK PERDGLFCEK IFGTTKDWEC
70 80 90 100 110 120
YCGKFKSIRY KGVVCDKCGV EVTHSKVRRE RMGHIELAAP VSHIWYYRSV PSRMGLLLDM
130 140 150 160 170 180
TINQLKSVLY FEKYVIIDPA DSGRNRGELI DEDEYHNYLD EYGDKFIAGI GGDAIKELLA
190 200 210 220 230 240
RIDVDAEARV IRQKIQDKNK ISDKRIFKRL EVLEAFRDSG NRPEWMVLDV VPVIPPELRP
250 260 270 280 290 300
MVQLEGGRFA TSDLNDLYRR VINRNNRLKR LLALKAPEII VRNEKRMLQE AVGALFDNSR
310 320 330 340 350 360
RKRTVKGKGN RPLKSISDML KGKQGRFRQN LLGKRVDYSG RSVIVVGPEL KYHQMGLPKK
370 380 390 400 410 420
MALELFKPFI MKRLVDLELA PNIKSAKKKI EAEDKEVFDV LETVVKEHPV LLNRAPTLHR
430 440 450 460 470 480
LGIQAFLPVL VEGKAIKLHP LVCHAFNADF DGDQMAIHVP LAPKAQLETW MLMLSPHNIL
490 500 510 520 530 540
NPANGQPICG PTQDIVLGIY YLTSEVKDAK GEGKFFTGLE EVMYAIETKT VEIRSKISVL
550 560 570 580 590 600
HEGKIIETTP GRLIFNQVMP KGYVYINRTL GDKETNKIIA DVYEKFGPGI TVVMLDEIKR
610 620 630 640 650 660
LGYRYATVFA PTISIDDIRV SPQKEGLVND ANKEVEKADM EYRKGIITNE ERRKKVIEIW
670 680 690 700 710 720
TKTNDRITEG MFKELEKDQA GFNPVYVMAA SGARGSKQQI RQLAGMRGLM AKPSGEIIEL
730 740 750 760 770 780
AIRSNFREGL GVLEFFISTH GARKGLADTA LKTADAGYLT RRLVDISQDV IVSEDDCGTK
790 800 810 820 830 840
ANITLGIVKE GENVIVSLAD RVFGRYTAED LVDPVTEKVV FPKDTLITRA LGQQIENLGY
850 860 870 880 890 900
DKIKVRSPLT CRSRHGICTK CYGMDMARLV PAEIGEAVGT IAAQSIGQPG TQLTMRTFHV
910 920 930 940 950 960
GGAASATIQE KEHKVPFRSL VKSINGRLVT NANGSKVFAR RGTIIVNRLI QEFNTESLSS
970 980 990 1000 1010 1020
VRIVDGQRLE KGEVFASQVG ESIEQRITSD QAGTVSLIGT TLRILGDDIV IPVKIGTILK
1030 1040 1050 1060 1070 1080
SEEGQIVEEN KALAEFDPYN EVAVSETAGT IVWEDLEIGK NVRRDVDPKT SNIILKVVEQ
1090 1100 1110 1120 1130 1140
KKDRLVPKVI VGSDGYSVPV DALLQFQNGD KVREGDVIFK IPSVAEKTRD ITGGLPRVDE
1150 1160 1170 1180 1190 1200
LFEARRPKDA CTLAEIDGKI EDKGEIVKEK RILYILPDSP EQEKVKVAIP IGKQIRVRQG
1210 1220 1230 1240 1250 1260
DFVKRGDQLD EGNFDPHDIL AIKGPSALHE YLVSEVQEVY RLQGVHINDK HIEVVVRSML
1270 1280 1290 1300 1310 1320
RKVIITDSGD TSFVNQQQVD KFLFDEENDR VEQEGGSPAQ GTPVLLGLTK ASLNTESYFS
1330 1340 1350 1360 1370 1380
AASFQETTKV LTDAAIKGKT DNLMGLKENV IIGHMIPAGT GMKKYRDIEV FKEMPGDLDW
1390 1400 1410 1420 1430
DLDSEEEEEE LSELSEAAPV STATLSKLVA EEDEDEDELE EEADDSDDED DDD