B0S104

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Finegoldia magna (strain ATCC 29328 / DSM 20472 / WAL 2508) (Peptostreptococcus magnus)
KEGG Pathway
fma:FMG_0626
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

24-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0S104

Entry ID Method Resolution Chain Position Source
AF-B0S104-F1 Predicted AlphaFoldDB

No variants for B0S104

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0S104

No associated diseases with B0S104

5 regional properties for B0S104

Type Name Position InterPro Accession
domain Forkhead-associated (FHA) domain 536 - 588 IPR000253
domain DHHA1 domain 732 - 862 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 647 - 690 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 548 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 703 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKNYGLNEIR KKFLDYFGER GHLVIKSFPL IPQDDKSLLL INAGMAPLKK YFTGEKKLKK
70 80 90 100 110 120
DRATSSQRCI RTADIDEVGK TQRHGTFFEM LGNFSFGDYF KREAITWAWD FLTNELEVPK
130 140 150 160 170 180
DILWVSVYEE DEEAYNIWVN EVGISPERVV KLGKADNFWE LDQGPCGPCS EIHVDRGFEF
190 200 210 220 230 240
DPREDAKPGD EGERFLEVWN LVFTQFNKTA DGKYERIAHP NIDTGMGLER ITMVLENADN
250 260 270 280 290 300
IFEIGLVKDI IKTIEEISGV KYKENHKNDV SIRIIADHVR AMTFLIYDGV IPSNEQRGYV
310 320 330 340 350 360
LRRLIRRACR HGKLLGINDS FIEKVIDSCI KVYESGYPEL KEDRDRIVKI ANAEEKKFQE
370 380 390 400 410 420
TLDLGLNILD SMLKETDSDV FSGENAFKLY DTYGFPIDLT KELVGEVNKT VDEVQFKKLM
430 440 450 460 470 480
EEQKERARGS RNESNMGWSS DKKYGEELPE TKFDGYNSLK DESKVIEIYG EDENNLKAGQ
490 500 510 520 530 540
MGIIVLDCTT FYGEGGGQVG DKGIIYNDNF KAEVYDTKKT GKKVFLHYVK VTEGSLHVGD
550 560 570 580 590 600
KVTIEVDELN RRDIMKNHSA THLLHQALKD VVGDHVNQAG SYVDGERLRF DITHFEAVSK
610 620 630 640 650 660
EQLEKVEQIV NDKIALGIPV KIDEMSLEES QSIGARGLFE DKYQDVVRVV QMGDYSIELC
670 680 690 700 710 720
GGTHVKTTSD IQMLKIISES SVAAGVRRIE AITGRAVYKY LKERDRLIDN VKHSLKASNE
730 740 750 760 770 780
DEITRRIEMN TEEIKGLKKK LKDITNKDLS SNVDSVINDA VEVNGTKVCT FELSGLDNNS
790 800 810 820 830 840
FRDFGENIKS KLEDGVVILA NSDESKVSFI ALVTDSSVKK GVFAGDIVRE VAKVCGGNGG
850 860 870
GRKDFAQAGA KDSSKVDEAL QKGIETVKSK LNA