B0S101

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Finegoldia magna (strain ATCC 29328 / DSM 20472 / WAL 2508) (Peptostreptococcus magnus)
KEGG Pathway
fma:FMG_0623
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

729-799 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0S101

Entry ID Method Resolution Chain Position Source
AF-B0S101-F1 Predicted AlphaFoldDB

No variants for B0S101

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0S101

No associated diseases with B0S101

5 regional properties for B0S101

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 43 - 53 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 417 - 607 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 653 - 764 IPR013155
domain Methionyl/Leucyl tRNA synthetase 40 - 183 IPR015413
domain Leucyl-tRNA synthetase, editing domain 221 - 403 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDKYNPNSIE KKWQKYWEEN KTFKTSDDKS KKRFYALVEF PYPSGQGLHV GHPRPYTALD
70 80 90 100 110 120
IVSRKRRMQG YNVLYPMGWD AFGLPTENFA IKNKIRPEVV TENNIKNFKR QMQSIGFSFD
130 140 150 160 170 180
WDREINTTDP DYYKWTQWIF IQMFKKGLAY KKEMPINWCP SCKTGLANEE VINGHCERCG
190 200 210 220 230 240
GQVVRKVKNQ WMLKITEYAD RLIDDLKDVD YFDRIKSQQI NWIGRSYGAE INFAVKEVDE
250 260 270 280 290 300
KITVFTTRAD TIFGATYMVI SVDHPLIEKY SDRIKNIDEI RSYRSEVAKK SELERTDLSK
310 320 330 340 350 360
EKTGYKIDGL TAINPLTNKE IPVYVSDYVL MTYGTGAIMA VPAHDDRDYE FAKKFNIEMI
370 380 390 400 410 420
PVIEGSDIQN CAFTETNEGN LINSGFLNGL TVDEAKEKMY EYIEEKEIGH KKTNYKLRDW
430 440 450 460 470 480
VFSRQRYWGE PIPLVYCEHC GWVPLDEKDL PLVLPKVDNY EPTDNGESPL SKIDDFVHTK
490 500 510 520 530 540
CPKCGRDAVR ETDTMPQWAG SSWYYLRYTD PHNDEAIASK ENLDYYTPVD WYNGGMEHTT
550 560 570 580 590 600
LHLLYSRFWH KFLYDIGVVP TKEPYMKRTS HGMILGDNNE KMSKSRGNVV NPDDIVRDFG
610 620 630 640 650 660
ADTLRCYEMF IGDFEKSAPW SENGVKGCRK FLDKVWRTQD LVDGDSNFEK METLIHQTIK
670 680 690 700 710 720
KVSEDYENLK FNTAIAQLMT LLNEFNNLDK ISKEQFKIFL ILLNPVCPHI TEEIWQRMGY
730 740 750 760 770 780
EGYVHESSWP EYDESKTILD VIELPIQVNG KLRATVEINR EASEDEVYEK AVKDDVVAKY
790 800
LENKNVVKKI YVKGRIFNII VK