B0R8D4

PR
Gene name
rpo1N
Protein name
DNA-directed RNA polymerase subunit Rpo1N
Names
DNA-directed RNA polymerase subunit A'
Species
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
KEGG Pathway
hsl:OE_4740R
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

89-419 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0R8D4

Entry ID Method Resolution Chain Position Source
AF-B0R8D4-F1 Predicted AlphaFoldDB

No variants for B0R8D4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0R8D4

No associated diseases with B0R8D4

6 regional properties for B0R8D4

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 387 - 553 IPR000722
domain RNA polymerase, N-terminal 277 - 581 IPR006592
domain RNA polymerase Rpb1, domain 3 556 - 707 IPR007066
domain RNA polymerase Rpb1, domain 1 8 - 385 IPR007080
domain RNA polymerase Rpb1, domain 5 846 - 916 IPR007081
domain RNA polymerase Rpb1, domain 4 733 - 839 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSAGQAPKEI GEISFGLMDP EEYRDMSATK VITADTYDDD GFPIDMGLMD PRLGVIDPGL
70 80 90 100 110 120
ECKTCGQRSG GCNGHFGHIE LAAPVIHVGF SKLIRRLLRG TCRECASLLL TEEEKDEYRE
130 140 150 160 170 180
NLDRTRSLRQ DVSDVMTAAI REARKKDHCP HCGEVQYDVK HEKPTTYYEV QQVLASDYSE
190 200 210 220 230 240
RIAASMQPDE DEDDAGVSPQ ELAEQTDIDI SRINEILSGE FRPRREDREA IETAIGADLT
250 260 270 280 290 300
TEDMNKLMPS DIRDWFEDIP GEDLEALGVN SDRSRPEWMI LTVLPVPPVT ARPSITLDNG
310 320 330 340 350 360
QRSEDDLTHK LVDIIRINQR FMENREAGAP QLIIEDLWEL LQYHVTTFMD NEISGTPPAR
370 380 390 400 410 420
HRSGRPLKTL SQRLKGKEGR FRGSLSGKRV NFSARTVISP DPTLSLNEVG VPDRVATEMT
430 440 450 460 470 480
QTMVVNEQNL ERARRYVRNG PEGHPGANYV TRPDGRRVRV TEKVCEELAE RVEPGWEVQR
490 500 510 520 530 540
HLIDGDIIIF NRQPSLHRMS IMAHEVVVMP YKTFRLNTVV CPPYNADFDG DEMNMHALQN
550 560 570 580 590 600
EEARAEARVL MRVQEQILSP RFGENIIGAI QDHISGTYLL TNDNPRFNET QASDLLRQTR
610 620 630 640 650 660
IDELPAAAGT DEDGDQYWTG HQIFSELLPD DLSLEFTGTT GDTVVIEDGQ LLEGTIADDE
670 680 690 700 710 720
VGEYGSEIVD TITKVHGNTR ARIFINEVAS LAMRSIMHFG FSIGIDDETV STEARERIDE
730 740 750 760 770 780
AIQSAYDRVQ ELIETYENGD LESLPGRTVD ETLEMKIMQT LGKARDSAGD VAEENFDEDN
790 800 810 820 830 840
PAVVMANSGA RGSMLNLTQM AGCVGQQAVR GERINRGYED RTLSHFAPND LSSEAHGFVE
850 860 870 880 890 900
NSYTSGLTPK EFFFHAMGGR EGLVDTAVRT SKSGYLQRRL INALSELETQ YDGTVRDTSD
910 920 930 940 950 960
TIVQFEFGED GTSPVQVSSN EEVDIDVEHV ADRILNSEFD SDTQKAEFLE VEEPPTNLSE
970
HGAAWEVESD D