B0K4I3

PR
Gene name
dapA
Protein name
4-hydroxy-tetrahydrodipicolinate synthase
Names
HTPA synthase
Species
Thermoanaerobacter sp (strain X514)
KEGG Pathway
tex:Teth514_2184
EC number
4.3.3.7: Amine-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

17-88 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0K4I3

Entry ID Method Resolution Chain Position Source
AF-B0K4I3-F1 Predicted AlphaFoldDB

No variants for B0K4I3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0K4I3

No associated diseases with B0K4I3

3 regional properties for B0K4I3

Type Name Position InterPro Accession
domain Dihydrodipicolinate reductase, N-terminal 2 - 124 IPR000846
domain Dihydrodipicolinate reductase, C-terminal 128 - 261 IPR022663
conserved_site Dihydrodipicolinate reductase, conserved site 146 - 163 IPR022664

Functions

Description
EC Number 4.3.3.7 Amine-lyases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
4-hydroxy-tetrahydrodipicolinate synthase activity Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O.

2 GO annotations of biological process

Name Definition
diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls.
lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPVFKGSGVA IVTPFNEEGV NFEKLGELIE WHIKEGTDAI IICGTTGEAS TMTQEEQQQA
70 80 90 100 110 120
IKFTVEKVAG RIPVIAGTGS NNTAHAVEMS EYAQSAGADA LLVITPYYNK TTQKGLVAHF
130 140 150 160 170 180
TEIARHVDIP IIIYNVPSRT SLNMLPETYL ELSKHVDNVV GVKEASGDIV QVAEIARIMG
190 200 210 220 230 240
KSFEIYSGND DQVIPIMSLG GLGVISVTAN IIPAKIHEMT TAYLNGDIEK ARDMQLELNP
250 260 270 280 290
LNKALFIETN PIPVKTAMNL MGFNVGPLRL PLVEMSDKNL EYLKSVLSKY GLLKEAN