B0K1A3

PR
Gene name
mutL
Protein name
DNA mismatch repair protein MutL
Names
Species
Thermoanaerobacter sp (strain X514)
KEGG Pathway
tex:Teth514_1612
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

58-132 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0K1A3

Entry ID Method Resolution Chain Position Source
AF-B0K1A3-F1 Predicted AlphaFoldDB

No variants for B0K1A3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0K1A3

No associated diseases with B0K1A3

3 regional properties for B0K1A3

Type Name Position InterPro Accession
conserved_site Translation initiation factor 3, conserved site 70 - 83 IPR019813
domain Translation initiation factor 3, N-terminal 19 - 84 IPR019814
domain Translation initiation factor 3, C-terminal 95 - 180 IPR019815

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mismatch repair complex Any complex formed of proteins that act in mismatch repair.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNKIHLLDEK TINKISAGEV VERPASIVKE LIENSIDAGS KNITVEILEG GIPYIKVSDD
70 80 90 100 110 120
GCGMNEIDAI LAFERHATSK IKSDNDLYSI GTLGFRGEAL ASIAAVSHVT LQTKEEGALF
130 140 150 160 170 180
GTKVVVEGGK VVEKTTCGCA KGCSIEVRDV FFNTPARRKF LKRPSTESMY IIDVVTKLCL
190 200 210 220 230 240
SHPEVSFKYV KDRKLQFITS GNGNIEDVIL RLFGNEVYSS LMSASFESED LKLKILAGKN
250 260 270 280 290 300
SLNYSNRNMQ FFYVNGRYVK NKTLSAAVDE AFKTYIPVNR YPAVFLYMEI DPRQIDVNIH
310 320 330 340 350 360
PSKLEIKFSD ERRIFEAVYK TIKDSLHKYN LIPEVKIEEK KNIFEIETPT ISAEQTKLYL
370 380 390 400 410 420
TSSDKELEEE KKKFDNEFKG KNVFLKDNVL KENSKNSSLD NHLAVYEEYE HEKEEINKND
430 440 450 460 470 480
LAKKISDIRI VGTLFSTYII VEKEDVFYII DQHAAHERIL YEKFTSQYEK IQTRQVTFPI
490 500 510 520 530 540
VVELQPRDLE LVHQEKELLN KLGYVFEEFG NNCIILREVP VILGQPEARQ LFIDIVEKLK
550 560 570 580 590 600
DKELINKISL KEENIIMMAC KAAVKAMDNL SEKEIHKLFD DLKITENPYT CPHGRPVIIA
610
ITKTQLEKMF KRIM