B0JL93

PR
Gene name
tig
Protein name
Trigger factor
Names
TF, PPIase
Species
Microcystis aeruginosa (strain NIES-843 / IAM M-2473)
KEGG Pathway
mar:MAE_62700
EC number
5.2.1.8: Cis-trans isomerases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0JL93

Entry ID Method Resolution Chain Position Source
AF-B0JL93-F1 Predicted AlphaFoldDB

No variants for B0JL93

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0JL93

1 associated diseases with B0JL93

[MIM: 619694]: Developmental delay with variable neurologic and brain abnormalities (DENBA)

An autosomal dominant disorder characterized by onset of motor and speech delay in early childhood. Disease severity and clinical manifestations are highly variable. Most patients have delayed walking and variably impaired intellectual development. Additional features may include seizures, spasticity, and ocular abnormalities. Brain imaging often shows thin corpus callosum and may show white matter atrophy, myelination abnormalities, or enlarged ventricles. {ECO:0000269|PubMed:32820033}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID
  • An autosomal dominant disorder characterized by onset of motor and speech delay in early childhood. Disease severity and clinical manifestations are highly variable. Most patients have delayed walking and variably impaired intellectual development. Additional features may include seizures, spasticity, and ocular abnormalities. Brain imaging often shows thin corpus callosum and may show white matter atrophy, myelination abnormalities, or enlarged ventricles. {ECO:0000269|PubMed:32820033}. Note=The disease is caused by variants affecting the gene represented in this entry.

3 regional properties for B0JL93

Type Name Position InterPro Accession
domain FKBP-type peptidyl-prolyl cis-trans isomerase domain 165 - 270 IPR001179
domain Trigger factor, C-terminal 270 - 425 IPR008880
domain Trigger factor, ribosome-binding, bacterial 1 - 149 IPR008881

Functions

Description
EC Number 5.2.1.8 Cis-trans isomerases
Subcellular Localization
  • Cytoplasm
  • About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

4 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKVIQEKLPA SQIGLEIEIP AETTKNTHEQ VVKNLAKSVN IPGFRPGKVP RQILLQRLGT
70 80 90 100 110 120
KAVKAAVIEE LIENCLESAL KQEGIESLGN PQLLSKFEDL IAAYEPGKAL TFSVSLDVAP
130 140 150 160 170 180
TIILGDYENL SVTAEETVYD PESVENWFKE RQEQLATLVP VEDRGAQLGD VAIVDYRGKS
190 200 210 220 230 240
AETGEDIPDI DGEDLRVDME AGRFIEGMVE GIIGMKPEEV KEMTLTFPED YPKEDVAAKA
250 260 270 280 290 300
VIFTITMKEL KAKELPELDD DFAQEVSDQE TIAELRASLE KRFQEQAEKE TKESIDDALT
310 320 330 340 350 360
KELVKGATLD LPETLIEKEV THILTQSFMQ FQQMGLDVNQ LFTKDNIPKM RENARPDAIE
370 380 390 400 410 420
SLKETLVVQE LAKVAGIEVS PEAVAEKIAN IMSQLSDRDI DMQRLEQVIT EEMLAENTLE
430 440 450 460
WLKEKATITL VPKGSLEEET SEEEETEETL AAAAVEVLAA EEEP