B0JL88

PR
Gene name
dxs
Protein name
1-deoxy-D-xylulose-5-phosphate synthase
Names
1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS
Species
Microcystis aeruginosa (strain NIES-843 / IAM M-2473)
KEGG Pathway
mar:MAE_62650
EC number
2.2.1.7: Transketolases and transaldolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

277-347 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0JL88

Entry ID Method Resolution Chain Position Source
AF-B0JL88-F1 Predicted AlphaFoldDB

No variants for B0JL88

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0JL88

No associated diseases with B0JL88

4 regional properties for B0JL88

Type Name Position InterPro Accession
domain Transketolase, N-terminal 28 - 47 IPR005474
domain Transketolase-like, pyrimidine-binding domain 318 - 484 IPR005475
binding_site Transketolase binding site 425 - 441 IPR020826
domain Transketolase, C-terminal domain 497 - 618 IPR033248

Functions

Description
EC Number 2.2.1.7 Transketolases and transaldolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
1-deoxy-D-xylulose-5-phosphate synthase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2).
magnesium ion binding Binding to a magnesium (Mg) ion.
thiamine pyrophosphate binding Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

3 GO annotations of biological process

Name Definition
1-deoxy-D-xylulose 5-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.
terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.
thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHLSEITHPN QLHGLSLRQL EDIARQIREK HLQTIAATGG HLGPGLGVVE LTIALYQTLD
70 80 90 100 110 120
LDRDKVLWDV GHQAYPHKLL TGRYNDFHTL RQKDGIAGYL KRCESKFDHF GAGHASTSIS
130 140 150 160 170 180
AGLGMALARD AKGEDFKVVS IIGDGALTGG MALEAINHAG HLPNTNIMVI LNDNEMSISP
190 200 210 220 230 240
NVGAISRYLN KVRLSEPVQF IADNLEEQFK NLPFFGDSLT PEMERVKEGM KRLAVPKVGA
250 260 270 280 290 300
VIEELGFKYF GPIDGHNIPE LIATFKQAHK VHGPVFVHVA TVKGKGYEWA EKDQVGYHAQ
310 320 330 340 350 360
NPFNLATGKP IPSSKPKPPA YSKVFGHTLT KLAENDPRII GITAAMATGT GLDKFQAKLP
370 380 390 400 410 420
KQYIDVGIAE QHAVTLAGGL ACEGMRPVVT IYSTFLQRAF DQIIHDICIQ NLPVFFCMDR
430 440 450 460 470 480
AGIVGADGPT HQGMYDIAYL RCIPNMTIMA PKDEAELQRM VVTGINHTSG PIAMRYPRGN
490 500 510 520 530 540
GLGVPLMEEG WEALPIGKGE ILRSGDDILL LGYGTMVNTS LQVAEILSEH GIEATVVNAR
550 560 570 580 590 600
FVKPLDTELI FPLAQRLGKV VTLEEGCLMG GFGSAVLEAL QDANILVPVK RFGVPDKLVD
610 620 630
HATPEESFAD LGLTSPQIAQ QVLAAFFSQK QTANVG