B0F0H3

PR
Gene name
mkrn2
Protein name
E3 ubiquitin-protein ligase makorin-2
Names
RING-type E3 ubiquitin transferase makorin-2
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
EC number
2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

33-192 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0F0H3

Entry ID Method Resolution Chain Position Source
AF-B0F0H3-F1 Predicted AlphaFoldDB

No variants for B0F0H3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0F0H3

No associated diseases with B0F0H3

5 regional properties for B0F0H3

Type Name Position InterPro Accession
domain GMP synthase, C-terminal 212 - 525 IPR001674
domain GMP synthase, glutamine amidotransferase 10 - 205 IPR004739
domain Glutamine amidotransferase 12 - 199 IPR017926
domain NAD/GMP synthase 223 - 257 IPR022310
domain GMP synthetase ATP pyrophosphatase domain 208 - 400 IPR025777

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
LIM domain binding Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.
metal ion binding Binding to a metal ion.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.

13 GO annotations of biological process

Name Definition
axis specification The establishment, maintenance and elaboration of a pattern along a line or around a point.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
embryo development ending in birth or egg hatching The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
negative regulation of inflammatory response to antigenic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
negative regulation of neurogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
negative regulation of NIK/NF-kappaB signaling Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
phosphatidylinositol 3-kinase signaling A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of transcription factor catabolic process Any process that activates or increases the frequency, rate or extent of transcription factor catabolic process.
protein kinase B signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSPKQVTCRY FLHGVCREGS RCLFSHDLAT SKPSTVCRFF LRGQCAYGTR CRYDHVKPCN
70 80 90 100 110 120
GTVFIPPQEM SPVLSPPPLF PAQEAAVPPT IPAPQRREKK TLVLRDRDLC GASVDPALQP
130 140 150 160 170 180
GCITESQGSE GEAKPHSYLE AICTGLDESQ DPASYPGAPQ QLCPFAQAGE CHCGDSCPYL
190 200 210 220 230 240
HGDACEICGL QVLHPHDQEQ RRDHEKLCME NFELDMERAF AVQASEGRVC SICMERVYEK
250 260 270 280 290 300
QSPAQRRFRI LSDCNHTYCL TCIRQWRCAR QFDNPVIKSC PECRVISEFV IPSAYWVEDQ
310 320 330 340 350 360
SKKDELIEAF KQGMGKKLCK YFDQGRGTCP FGGKCLYLHS YPDGTRAQPE KPRKQLGSEG
370 380 390 400
SVRFLNSLRL WDFIEDREQR GVPNAEVGKL GELFMHLSGA DEELPAPFN