B0CM26

PR
Gene name
CFAP69
Protein name
Cilia- and flagella-associated protein 69
Names
Species
Papio anubis (Olive baboon)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0CM26

Entry ID Method Resolution Chain Position Source
AF-B0CM26-F1 Predicted AlphaFoldDB

No variants for B0CM26

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0CM26

No associated diseases with B0CM26

4 regional properties for B0CM26

Type Name Position InterPro Accession
domain tRNA(Ile)-lysidine/2-thiocytidine synthase, N-terminal 25 - 208 IPR011063
domain tRNA(Ile)-lysidine synthase, N-terminal 24 - 212 IPR012795
domain Lysidine-tRNA(Ile) synthetase, C-terminal 388 - 460 IPR012796
domain tRNA(Ile)-lysidine synthase, substrate-binding domain 261 - 330 IPR015262

Functions

Description
EC Number
Subcellular Localization
  • Cell projection, cilium
  • Cell projection, cilium, flagellum
  • Localizes to the midpiece of the sperm flagellum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
non-motile cilium A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.
sperm midpiece The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

7 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
olfactory behavior The behavior of an organism in response to an odor.
positive regulation of fertilization Any process that activates or increases the frequency, rate or extent of fertilization.
positive regulation of flagellated sperm motility Any process that activates or increases the frequency, rate or extent of flagellated sperm motility.
response to odorant Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell.
sensory perception of smell The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MWTEEAAATA EARESGIRNK SSSSSQIPVV GVVTEDNEAQ GVFKPMDLNR VIKLLEETDK
70 80 90 100 110 120
DGLEEKQLKF VKKLVQCFQN GLPLRDLAQI FKILNLCAGK IKNQPRFVES AYDIIKLCSL
130 140 150 160 170 180
PFLKKKVSDE ITYAEDTANS IALLGDLMKI PSSELRIQIC KCIVDFYHAE PPKKHIPGYQ
190 200 210 220 230 240
QASSSYKIQM AEVGGLAKTM VQSITLLEHQ LVEKLWVLKV LQHLSTSEVN CTIMMKAQAA
250 260 270 280 290 300
SGICTHLNDP DPSGQLLFRS SEILWNLLEK SSKEEVIQQL SNLECLLALK EVFTNLFMRG
310 320 330 340 350 360
FSHYDRQLRN DILVITTIIA QNPEAPMIEC GFTKDLILFA TFNEVKSQNL LVKGLKLSNS
370 380 390 400 410 420
YEDFELKKLL FNVIVILCKD LPTVQLLIDG KVILALFTYV KKPEKQKIMG WSAAQHEELQ
430 440 450 460 470 480
LHAIATLSSV APLLIEEYMS CQGNARVLAF LEWCESEDPF FSHGNSFHGT GGRGNKFAQM
490 500 510 520 530 540
RYSLRLLRAM VYLEDETVNT DLCEKGTIQQ MIGIFKNIIS KPNEKEEAIV LEIQSDILLI
550 560 570 580 590 600
LSGLCENHIQ RKEIFGTEGV DIVLHVMKTD PRKLQSGLGY NLLLFSTLDS IWCCILGCYP
610 620 630 640 650 660
SEDYFLEREG IFLLLDVLAL NQKKFCNLIL GIMVEFCDNP KTAAHVNAWQ GKKDQTAASL
670 680 690 700 710 720
LIKLWRKEEK ELGVKRDKNG KIIDTKKPLF TSFQEEHKII PLPANCPSIA VMDVSENIRA
730 740 750 760 770 780
KIYAILGKLD FENLPGLSAE DFVTLCVIHR YLDFKIGEIW NEIYEEIKLE KLRPVTIDKK
790 800 810 820 830 840
ALEAITTASE NVGKMVASLQ SEIIESQARQ DVQNEQKVYA KIQATHKQRE LANKSWENFL
850 860 870 880 890 900
ARTSNAKTLK KAKRLQEKAI EASRYHKRPQ NAVFHGTDIK GLNTTVPSGG VVTVESTPAR
910 920 930 940
LVGGPLADTD IALKKLPIRG GALQRVKAVE IVDAPKKSIP T