B0B8F5

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
KEGG Pathway
ctb:CTL0844
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

191-266 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0B8F5

Entry ID Method Resolution Chain Position Source
AF-B0B8F5-F1 Predicted AlphaFoldDB

No variants for B0B8F5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0B8F5

No associated diseases with B0B8F5

7 regional properties for B0B8F5

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 312 - 522 IPR002314
domain TGS 1 - 58 IPR004095
domain Anticodon-binding 535 - 624 IPR004154
domain Aminoacyl-tRNA synthetase, class II 261 - 528 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 164 - 213 IPR012947
domain Threonine-tRNA ligase catalytic core domain 237 - 533 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 533 - 623 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIHVTCNQEA FELPEGASAM DLANKMKQSH CFVGALINDQ EKDLSTTLQD GDTVLFLTWD
70 80 90 100 110 120
DPKGREIFLH TSAHILAQAV LRLWPSAQPT IGPVIDQGFY YDFANLSISE EDFPAIEAMA
130 140 150 160 170 180
KTIAEEKFPI SRQVFPDKEA ALAYFSQNPF KAELIAELPE EVEISAYTQG EFLDLCRGPH
190 200 210 220 230 240
LPSTAPVKAF KLLRTSSAYW KGDPSRESLI RIYGVSFPTT KELKEHLHQL EEAKKRDHRV
250 260 270 280 290 300
LGTKLDLFSQ QTCSAGMPFF HPRGMVVWNA LVDYWKRLHQ RAGYQQIQTP QLMNRELWEI
310 320 330 340 350 360
SGHWENYKEN MYTLTVDEED YAIKPMNCPG CMLYYKTQLH SYREFPLRIA EIGHVHRHEL
370 380 390 400 410 420
SGALSGLMRV RTFHQDDAHV FLTPEQVEEE TLNILNLVSE LYGTFGLEYH LELSTRPEQG
430 440 450 460 470 480
TIGSDDLWEL ATEALKRALV KSQKPFIISP GEGAFYGPKI DIHVKDAINR TWQCGTIQLD
490 500 510 520 530 540
MFLPERFDLK YTNAQGEKST PIMLHRALFG SIERFLGILI EHFKGRFPLW LSPEHVRIIT
550 560 570 580 590 600
VADRHEARAQ ELAKHFSQMG IIVSVDSSNE SVSKKIRNAQ NMQVNYMITI GDKELETHLL
610 620 630
AVRTRDNRVL NDIAVEQFSH VILEELRSLS LTPSL