A9WK04
Gene name |
lysS |
Protein name |
Lysine--tRNA ligase |
Names |
Lysyl-tRNA synthetase, LysRS |
Species |
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) |
KEGG Pathway |
cau:Caur_1226 |
EC number |
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A9WK04
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A9WK04-F1 | Predicted | AlphaFoldDB |
No variants for A9WK04
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A9WK04 | |||||
No associated diseases with A9WK04
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.6 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| lysine-tRNA ligase activity | Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| tRNA binding | Binding to a transfer RNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| lysyl-tRNA aminoacylation | The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELNDLQAQR | AAKLAELRAA | GLDPYPPRCY | RSHTIAEALA | AFDDLVAQST | TLTLTGRIIG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ARRIMGKIAF | AHIEDGTGEI | QLWLSRADLG | DEWFERFRDQ | LDTFDIVQAS | GVLRCTKTGE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RSLFVRELAI | LAKAINPPPE | KWAGLQDVEE | RHRQRYLDLI | VNRDRREIFR | ARARVISTMR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RVLDERGFLE | VETPVLQPLY | GGAAARPFIT | YHNALGQNLY | LRIATELYLK | RLIVGGFPGV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YEIGKNFRNE | GVDRSHNPEF | TMMECYQAYA | DYHAMMTLVE | EMLSEICLAV | HGTTTITYQG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RELDFRPPWP | RIAMATAIAD | RTGIDITQIT | DLDALQEAIS | ARGLRVERKA | SWAKQVDELF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SEFVQPHLFQ | PTFIIDYPVA | MSPLAKRIPD | RPDFTERFEA | FIAGMEIGNA | FTELNDPFDQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EERFREQLRA | FAAGDEEAHQ | MDEDFINALR | YGMPPTGGLG | VGIDRLVMVL | TDQSNIREVI |
| 490 | |||||
| LFPHLRERSD | E |