A9WCR2

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
KEGG Pathway
cau:Caur_3847
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

395-476 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A9WCR2

Entry ID Method Resolution Chain Position Source
AF-A9WCR2-F1 Predicted AlphaFoldDB

No variants for A9WCR2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A9WCR2

No associated diseases with A9WCR2

4 regional properties for A9WCR2

Type Name Position InterPro Accession
domain DHHA1 domain 750 - 888 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 658 - 713 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 558 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 726 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

6 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents.
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.
tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQKLTAAQIR ETFLSFFIRH GHTHVPSSSL VVADDPTLLF ANSGMVQFKD VFLGREQRPY
70 80 90 100 110 120
SRAVTAQKCL RVSGKHNDLE EVGPSPRHHT FFEMLGNFSF GDYFKAEAIA LAWKLLTEEF
130 140 150 160 170 180
KLPVERLWFT VFAGDDEVPP DDEAAALWIA QGADPSRVLR FGRKDNFWVM GDTGPCGPCS
190 200 210 220 230 240
EITMYIGDDL SQMRAEGVNS DDPNYVEIWN NVFMQYDRAT MQPLPRPSVD TGMGLERMAM
250 260 270 280 290 300
VMQGVHSTYE TDLFVAIINQ IIKTRGSDEE HYHAHRSAYR AIADHARAIA FLIADGVLPG
310 320 330 340 350 360
NLGRSYVLRR ILRRAAYQGR TIGFERPFLA DVITSVIEQM GEAYPELVKR RELILSAADQ
370 380 390 400 410 420
EERQFLRTLS GGLTRLQGVI EQVRARGEQV IPGNDAFVLK DTYGFPLDLT QKIAAEQGLT
430 440 450 460 470 480
VDEAGYEAAM AEQRARSRAA AASKRGGEAD LWADLDLPAS HFTGYERLSD RATVIGMLGD
490 500 510 520 530 540
GDALTSADTG RSVQIVLDTT PFYAESGGQI GDTGLLVGPE GSVQIEDTRR PLPGLIVHYG
550 560 570 580 590 600
RVVNGRISVG DQVQATVDVV RRADIQRNHT ATHMLQRALR DVLGEHAAQA GSLVAPDRLR
610 620 630 640 650 660
FDFTHTKAVD PEELREVEQR LNKWVRADTT VRWEITGYQD AMARGAIALF GEKYGDTVRL
670 680 690 700 710 720
VTIERGQTLA EGEFASRDSL ELCGGTHVNH TGEIGFVRIV SEGSIGSGIR RIEALTGRGA
730 740 750 760 770 780
EGWVEQQAQT LRELAARINT QPAQLLERID ALLAEHRQRK QELEALRSKL AREQLDLLLG
790 800 810 820 830 840
RVQHVAGVPL LAAEVEADSV DRLREMGEYL RDKLGNAVIV LGAQINGKPQ LLTIVTPDLV
850 860 870 880 890
RRGLNAVQLV KPLAALVGGG GGGRPEIAQA GGRHPDKLAA AIGAAVEVLA GQAG