A9WCA1

PR
Gene name
ligA
Protein name
DNA ligase
Names
Polydeoxyribonucleotide synthase [NAD(+)]
Species
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
KEGG Pathway
cau:Caur_0241
EC number
6.5.1.2: Forming phosphoric ester bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

653-709 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A9WCA1

Entry ID Method Resolution Chain Position Source
AF-A9WCA1-F1 Predicted AlphaFoldDB

No variants for A9WCA1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A9WCA1

No associated diseases with A9WCA1

10 regional properties for A9WCA1

Type Name Position InterPro Accession
domain BRCT domain 602 - 681 IPR001357
domain Helix-hairpin-helix DNA-binding motif, class 1 457 - 476 IPR003583-1
domain Helix-hairpin-helix DNA-binding motif, class 1 491 - 510 IPR003583-2
domain Helix-hairpin-helix DNA-binding motif, class 1 555 - 574 IPR003583-3
domain Zinc-finger, NAD-dependent DNA ligase C4-type 418 - 445 IPR004149
domain NAD-dependent DNA ligase, OB-fold 333 - 409 IPR004150
domain NAD-dependent DNA ligase, adenylation 6 - 329 IPR013839
domain NAD-dependent DNA ligase, N-terminal 5 - 459 IPR013840
active_site NAD-dependent DNA ligase, active site 117 - 146 IPR018239
domain DisA/LigA, helix-hairpin-helix motif 521 - 584 IPR041663

Functions

Description
EC Number 6.5.1.2 Forming phosphoric ester bonds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA ligase (NAD+) activity Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
base-excision repair, DNA ligation The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSHTTVADRI NELRSLIRRY DYHYYVLDDP IVSDAEYDAL MTELRALEAA HPELITPDSP
70 80 90 100 110 120
TQRVSGTPAS QFAKVQHPQP MLSLGNAFTK ADLLAWRDRV LRLLGPDAIV AYVVEPKIDG
130 140 150 160 170 180
LAVALTYRDG RLVQGATRGD GEVGEDVTAN LRTIGSIPLT LQATSTPQDD DLPTTLPTTI
190 200 210 220 230 240
EVRGEVYMRT ADFETLNDRL AAAGEKIFAN PRNAAAGSLR QKDPTITAAR PLRFFAYGVG
250 260 270 280 290 300
VVEGISLSSQ WQTLRYLRAL GFPVNQDVRR FTDFAEVLAY CEAWMAKRDD LPYEADGVVI
310 320 330 340 350 360
KIDDFAQQRE LGVVGRDPRW AIAFKFPARE AITRLLDITV NVGRTGVVTP NAELEPVQIG
370 380 390 400 410 420
GVTVRNASLH NADYIAQRDI RIGDYVIVKR AGDVIPYVVG PVIARRDGSE RPWQFPTHCP
430 440 450 460 470 480
ACGSPLEREE GEAAWRCNNF SICPAQLVRR VEHFVSRSAL DIVGMGERQA ELFVQRGLIR
490 500 510 520 530 540
DVADIFFLKA DQLAELEGFG PKRIANLLAA IDAARQRPLD RLLVGLGIRY VGTVAAQTLV
550 560 570 580 590 600
AALGSLDAIM AARQEELEQI PGIGPVVAAS IVDFFSRPAN RALIEKLRAA GVQMGGVSGP
610 620 630 640 650 660
TRQSDTLAGK TFVLTGTLPS LSREQASALI VAHGGKVTDS VSKKTSYVVA GANAGSKLAK
670 680 690 700
ALQLGIPVID EAGLLALIGT TAEPPPSPPP PPPETNTDGN QLLLPLDGE